Classics in Total Synthesis III

Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods.

?The present volume?and hopefully future books of this series?offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety. Classics in Total Synthesis III will surely itself become a classic in the literature on the state of the art of contemporary organic synthetic chemistry.? ? Angewandte Chemie Int. Ed. 2011

"... a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire." ?JACS (on a previous volume)

"...this superb book (...) will be an essential purchase for many organic chemists." ?Nature (on a previous volume)

"... One of my co-workers confessed that Classics I was the book on his bedside table while he prepared his thesis defense. Isn't that the highest distinction for a monograph?" ?Angewandte Chemie, 2004 (on a previous volume)

Auteur
K.C. Nicolaou holds joint appointments at The Scripps Research Institute, where he is the Chairman of the Department of Chemistry and holds the Darlene Shiley Chair in Chemistry and the Aline W. and L.S. Skaggs Professorship of Chemical Biology, and the University of California, San Diego, where he is Distinguished Professor of Chemistry. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens. For his contributions to science and education, he was elected Fellow of the New York Academy of Sciences, Fellow of the American Academy of Arts and Sciences, Member of the National Academy of Sciences, USA, Member of the German Academy of Sciences Leopoldina, and Corresponding Member of the Academy of Athens, Greece. He is the recipient of many prizes, awards and honors.

Jason S. Chen received his A.B. and A.M. degrees in Chemistry from Harvard University in 2001. After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.C. Nicolaou. He received a National Defense Science and Engineering Graduate fellowship, and completed his Ph.D. studies in 2008. He currently is a post-doctoral fellow in Professor Nicolaou's laboratory.

Texte du rabat

Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou and his student Jason S. Chen compile here the important strategies and tools employed to construct complex molecules. Through 42 syntheses of 25 challenging natural products they explain the key steps of the synthetic pathway, highlighting the major developments for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing a trilogy, this textbooks analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces.
A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists.

From reviews of "Classics in Total Synthesis", Volumes I and II:

"...a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire."
JACS

"...this superb book (...) will be an essential purchase for many organic chemists."
Nature

"... Classics II is undoubtedly an excellent bargain that is highly recommended to everybody interested in advanced organic chemistry..."
Angewandte Chemie

Contenu
INTRODUCTION: THE ADVANCING FIELD OF TOTAL SYNTHESIS
Targets
Strategies and Methods
Classics in Total Synthesis III

TETRODOTOXIN
Introduction
Kishi's Retrosynthetic Analysis and Strategy
Kishi's Total Synthesis
Du Bois' Retrosynthetic Analysis and Strategy
Du Bois' Total Synthesis
Conclusion

DISCODERMOLIDE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

AZASPIRACID-1
Introduction
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis
Evans' Retrosynthetic Analysis and Strategy
Evans' Total Synthesis
Conclusion

THIOSTREPTON
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

PENTACYCLOANAMMOXIC ACID METHYL ESTER
Introduction
First-Generation Retrosynthetic Analysis and Strategy
First-Generation Total Synthesis
Second-Generation Retrosynthetic Analysis and Strategy
Second-Generation Total Synthesis
Conclusion

LITTORALISONE, OSELTAMIVIR (TAMIFLU®), AND HIRSUTELLONE B
Introduction
Introduction to Littoralisone
Total Synthesis of Littoralisone
Introduction to Oseltamivir (Tamiflu®)
Total Synthesis of Oseltamivir (Tamiflu®)
Introduction to Hirsutellone B
Total Synthesis of Hirsutellone B
Conclusion

RUBICORDIFOLIN AND RUBIONCOLIN B
Introduction
Retrosynthetic Analysis of Rubicordifolin
Total Synthesis of Rubicordifolin
Retrosyntheticd Analysis of Rubioncolin B
Total Synthesis of Rubioncolin B
Conclusion

CYANTHIWIGINS U AND F
Introduction
Phillips' Retrosynthetic Analysis and Strategy
Phillips' Total Synthesis
Stolz' Retrosynthetic Analysis and Strategy
Stoltz' Total Synthesis
Conclusion

STEPHACIDIN B
Introduction
Myers' Retrosynthetic Analysis and Strategy
Meyers' Total Synthesis
Baran's Retrosynthetic Analysis and Strategy
Baran's Total Synthesis
Williams' Retrosynthetic Analysis and Strategy
Williams' Total Synthesis
Conclusion

ABYSSOMICIN C AND ATROP-ABYSSOMICIN C
Introduction
Sorensen's Retrosynthetic Analysis and Strategy
Sorensen's Total Synthesis of Abyssomicin C
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis of Abyssomicin C and atrop-Abyssomicin C
Conclusion

TETRACYCLINE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

BISANTHRAQUINONE NATURAL PRODUCTS
Introduction
Retrosynthetic Analysis and Strategy Toward 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Total Synthesis of 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Retrosynthetic Analysis and Strategy Toward Antibiotic BE-43472B
Total Synthesis of Antibiotic BE-43472B
Conclusion

GARSUBELLIN A
Introduction
Sibasaki and Kanai's Retrosynthetic Analysis and Strategy
Shibasaki and Kanai's Total Synthesis
Danishefsky's Retrosynthetic Analysis and Strategy
Danishefsky's Total Synthesis
Conclusion

WELWITINDOLINONE A
Introduction
Baran's Retrosynthetic Analysis and Strategy
Barans' Total Synthesis
Wood's Retrosynthetic Analysis and Strategy
Wood's Total Synthesis
Conclusion

IEJIMALIDE B
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

KEDARCIDIN CHROMOPHORE AND MADUROPEPTIN CHROMOPHORE
Introduction
Retrosynthetic Analysis and Strategy for Kedarcidin Chromophore
Total Synthesis of Kedarcidin Chromophore
Retrosynthetic Analysis and Strategy for Maduropeptin Chromophore
Total Synthesis of Maduropeptin Chromophore
Conclusion

BIYOUYANAGIN A
Introduction
Retrosynthetic Analysis and Strategy
Total Synthes…