Fundamental Toxicology

Klappentext This book is a core introductory text to the subject of toxicology and the use of toxicological information for risk assessment by chemists. Increasingly, chemists are being required by law to advise on the safe handling of chemicals. Few chemists, however, have been trained in toxicology, and the subject is often not covered in a chemistry degree curriculum. It is to address this problem that this book has been written. Fundamental Toxicology for Chemists contains a proposed curriculum for teaching toxicology to chemists, which gives a firm grounding in the basics. With this book as a guide, lecturers will be able to design courses that cover all their students needs. In addition, students in all areas of chemistry will find it invaluable. Fundamental Toxicology for Chemists offers a unique assessment of the subject specifically for chemists. It is both comprehensible and fully comprehensive, covering developing areas such as reproduction, behavioural and ecological toxicology. The book has been approved by the IUPAC (International Union of Pure and Applied Chemists) committees on toxicology and the teaching of chemistry. It has a comprehensive index and an extensive glossary of terms, and will have lasting value to all chemists as a reference, and a text book. Zusammenfassung Fundamental Toxicology is a comprehensive review of toxicology. It is based on the highly successful 'Fundamental Toxicology for Chemists' and has been enriched and expanded. Inhaltsverzeichnis Chapter 1: Introduction to Toxicology; 1.1: Introduction;1.2: Exposure to Potentially Toxic Substances;1.3: Adverse Effects;1.5: Tolerance and Resistance; 1.6: Toxicity Testing; 1.7: Epidemiology and Human Toxicology; 1.8: Bibliography; Chapter 2: Introduction to Toxicodynamics; 2.1: Introduction; 2.2: Dose-Toxicity Relationships; 2.3: Toxicity Testing and Health Risk; 2.4: Bibliography; Chapter 3: Toxicokinetics; 3.1: Introduction; 3.2: Absorption; 3.3: Distribution; 3.4: Elimination; 3.5: Chronic Administration; 3.6: Saturation Kinetics; 3.7: Toxicokinetics and Risk Assessment; 3.8: Conclusions; 3.9: Bibliography; Chapter 4: Data Interpretation; 4.1: Introduction; 4.2: Risk Analysis and Risk Mangement; 4.3: Data Retrieval; 4.4: Types of Data; 4.5: Handling Quantitative Data Using Statistical Analysis; 4.6: Evaluation of Experimental Data; 4.7: Errors and Faults in Data Interpretation; 4.8: Conclusion; 4.9: Bibliography; Chapter 5: Risk Assessment; 5.1: Introduction; 5.2: Definitions; 5.3: Process of Risk Assessment; 5.4: Hazard Identification and Characterisation; 5.5: Risk Characterisation; 5.6: Conclusions; 5.7: Bibliography; Chapter 6: Risk Management; 6.1: Introduction; 6.2: The Risk Evaluation and Management Process; 6.3: Risk Considerations; 6.4: Criteria for Risk Evaluations: Human Health; 6.5: Criteria for Risk Evaluation: Environment; 6.6: Tolerable Risk; 6.7: Criteria for Risk Evaluation: Further Comments; 6.8: Risk Management; 6.9: Conclusions; 6.10: Bibliography; Chapter 7: Exposure and Monitoring; 7.1: Introduction; 7.2: General Principles; 7.3: Criteria for a Monitoring Programme; 7.4: Biomarkers and Sensitivity Screening; 7.5: Ethical Consideration; 7.6: Bibliography; Chapter 8: Risk Management; 8.1: Introduction; 8.2: Structure of DNA (Deoxyribonucleic Acid); 8.3: Types of Genetic Damage; 8.4: Repair of Damaged DNA; 8.5: Chromosomal; 8.6: Transmissible Human Genetic Damage; 8.7: Tests for Genetic Toxicity; 8.8: Conclusion; 8.9: Bibliography; Chapter 9: Carcinogenicity; 9.1: Introduction; 9.2: Mechanisms of Carcinogenicity; 9.3: Tests for Carcinogens; 9.4: Epidemiology; 9.5: Conclusions; 9.6: Bibliography; Chapter 10: Introduction to Toxicogenomics; 10.1: Introduction; 10.2: Microarray Technology; 10.3: Proteomics; 10.4: Metabonomics Overview; 10.5: Conclusion; 10.6: Bibliography; Chapter 11: Reproductive Toxicology; 11.1: Introduction; 11.2: Risk Assessment for Reproductive Toxicity; 11.3: Th...

Résumé
Fundamental Toxicology is a comprehensive review of toxicology. It is based on the highly successful 'Fundamental Toxicology for Chemists' and has been enriched and expanded.

Contenu

Chapter 1: Introduction to Toxicology; 1.1: Introduction;1.2: Exposure to Potentially Toxic Substances;1.3: Adverse Effects;1.5: Tolerance and Resistance; 1.6: Toxicity Testing; 1.7: Epidemiology and Human Toxicology; 1.8: Bibliography; Chapter 2: Introduction to Toxicodynamics; 2.1: Introduction; 2.2: Dose-Toxicity Relationships; 2.3: Toxicity Testing and Health Risk; 2.4: Bibliography; Chapter 3: Toxicokinetics; 3.1: Introduction; 3.2: Absorption; 3.3: Distribution; 3.4: Elimination; 3.5: Chronic Administration; 3.6: Saturation Kinetics; 3.7: Toxicokinetics and Risk Assessment; 3.8: Conclusions; 3.9: Bibliography; Chapter 4: Data Interpretation; 4.1: Introduction; 4.2: Risk Analysis and Risk Mangement; 4.3: Data Retrieval; 4.4: Types of Data; 4.5: Handling Quantitative Data Using Statistical Analysis; 4.6: Evaluation of Experimental Data; 4.7: Errors and Faults in Data Interpretation; 4.8: Conclusion; 4.9: Bibliography; Chapter 5: Risk Assessment; 5.1: Introduction; 5.2: Definitions; 5.3: Process of Risk Assessment; 5.4: Hazard Identification and Characterisation; 5.5: Risk Characterisation; 5.6: Conclusions; 5.7: Bibliography; Chapter 6: Risk Management; 6.1: Introduction; 6.2: The Risk Evaluation and Management Process; 6.3: Risk Considerations; 6.4: Criteria for Risk Evaluations: Human Health; 6.5: Criteria for Risk Evaluation: Environment; 6.6: Tolerable Risk; 6.7: Criteria for Risk Evaluation: Further Comments; 6.8: Risk Management; 6.9: Conclusions; 6.10: Bibliography; Chapter 7: Exposure and Monitoring; 7.1: Introduction; 7.2: General Principles; 7.3: Criteria for a Monitoring Programme; 7.4: Biomarkers and Sensitivity Screening; 7.5: Ethical Consideration; 7.6: Bibliography; Chapter 8: Risk Management; 8.1: Introduction; 8.2: Structure of DNA (Deoxyribonucleic Acid); 8.3: Types of Genetic Damage; 8.4: Repair of Damaged DNA; 8.5: Chromosomal; 8.6: Transmissible Human Genetic Damage; 8.7: Tests for Genetic Toxicity; 8.8: Conclusion; 8.9: Bibliography; Chapter 9: Carcinogenicity; 9.1: Introduction; 9.2: Mechanisms of Carcinogenicity; 9.3: Tests for Carcinogens; 9.4: Epidemiology; 9.5: Conclusions; 9.6: Bibliography; Chapter 10: Introduction to Toxicogenomics; 10.1: Introduction; 10.2: Microarray Technology; 10.3: Proteomics; 10.4: Metabonomics Overview; 10.5: Conclusion; 10.6: Bibliography; Chapter 11: Reproductive Toxicology; 11.1: Introduction; 11.2: Risk Assessment for Reproductive Toxicity; 11.3: Thresholds in Reproductive Toxicology; 11.4: Screening Tests in Animals for Reproductive Toxicity; 11.5: Extrapolation of Results of Animal Studies to Humans; 11.6: The European Community Classification of Chemicals for Reproductive Toxicity; 11.7: The 7th Amendment to EC Directive 67/548/EEC 1992; 11.8: Classification of Chemicals as Toxic for Reproduction; 11.9: Categorisation; 11.10: Lactation; 11.11: Testing Requirements under the Dangerous Substances Directive; 11.12: Downstream Consequences Relating to the Classification of Chemicals (CMR Substances); 11.13: Bibliography; Chapter 12: Immunology and Immunotoxicology; 12.1: Introduction; 12.2: Innate Immunity; 12.3: Adaptive Immunity; 12.4: Humoral Immunity; 12.5: Cell Mediated Immunity; 12.6: Delayed Type Hypersensitivity; 12.7: Complement; 12.8: Hypersensitivity; 12.9: Immunodeficiency; 12.10: Autoimmunity; 12.11: Transplantation; 12.12: Vaccination; 12.13: Immunotoxicity; 12.14: Bibliography; Chapter 13: Skin Toxicity; 13.1: Introduction; 13.2: Skin Anatomy; 13.3: Permeation; 13.4: Potency; 13.5: Dermal Toxicology; 13.6: Dermatitis; 13.7: Toxin Accumulation, Metabolism and Transport; 13.8: Chemical Carcinogenesis; 13.9: Ultraviolet Radiation; 13.10: Enzymes; 13.11: Peroxisomes; 13.12: Conclusions; 13.13: Bibliography; Chapter 14: Respiratory Toxicology; 14.1: Introduction; 14.2: Structure an…