Pharmaceutical Chemistry

A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition. This edition includes over 30 new illustrations, numerous new mechanistic schemes and enhanced original figures. In addition, the use of color makes its study more pleasant and impressive.

The Second Edition has been thoroughly revised with a modern look. The chapters on QSAR and Drug Metabolism have been extended, emphasizing concepts, such as the hyperconjugative effect or the anomeric effect, in which the student normally finds it difficult to understand. Stereoelectronic effects are essential to explain the mechanism of action of drugs and therefore, its agile and intuitive handling will allow the student access to both chemical and biological mechanisms, in a more rational way. The text is illustrated with hundreds of formulas and many tables that facilitate the understanding of this interesting discipline, which is halfway between Organic Chemistry, Biochemistry and Pharmacology. This Volume is aimed at building basis principles on drug design and it is likely to be of interest to students reading, pharmacy, pharmacology, and pharmaceutical chemistry.

This book emphasizes general principles of drug design and drug action from an organic chemical perspective, rather than from the overview of specific classes of drugs, allowing the reader to extrapolate information to many related classes of drug molecules. This volume presents an organic chemistry's perspective of how drug are designed and assuming no prior knowledge of biochemistry, and pharmacology. It is written in an informal, clear style so that undergraduates can easily understand the concepts presented. Drugs and Their Biological Targets is tretaed in a separate volume ISBN 978-3-11-131655-0.

Auteur

JOAQUÍN M. CAMPOS received B.Sc. and Ph.D. degrees from the University of Granada (UGR). He is full Professor in Medicinal and Organic Chemistry. He worked with Professor Ganellin, co-inventor of cimetidine (Tagamet®), at UCL (University College London, UK). He has published 175 papers in international journals with a high impact index, mainly in the fields of Organic Chemistry, Medical Chemistry and Cancer, 14 books and 14 book chapters, 13 national and 17 international patents and supervised 15 Doctoral Theses. He has been involved, for the most part as a responsible researcher in 18 research projects, and 3 research contracts with private companies. He advised the University of São Paulo (Brazil) on novel anticancer and anti-Alzheimer drugs, during the years 2015-17 as Special Visiting Professor. He was awarded the 2010 Teaching Excellence Award from the University of Granada. On March 17, 2016, he received the award from the Social Council of the University of Granada. He is Regional Editor in Europe for the journal Current Medicinal Chemistry, since August 13, 2016. Current Medicinal Chemistry is a leading journal in the field of Medicinal Chemistry.

As a consequence of his interest in raising the level of internationalization of the UGR and more specifically that of the Faculty of Pharmacy of the UGR, he has been teaching Pharmaceutical Chemistry in the Pharmacy Degree in English for many years, with excellent acceptance among students.