Autosomal Dominant Alzheimer's Disease

Texte du rabat

Biomarkers play an indispensable role in Alzheimer's Disease (AD) diagnosis, clinical research and clinical trials. Our understanding of AD biomarkers has been profoundly impacted by the study of Autosomal Dominant Alzheimer's Disease (ADAD). Though memory loss is the most common feature of ADAD, motor dysfunction, neuropsychiatric symptoms, and epileptiform abnormalities are present at a much higher rate in ADAD than sporadic, late-onset AD. There are over 250 known ADAD-causative variants in PSEN1, 2, and APP. This genetic heterogeneity is reflective in both biomarkers and cognitive heterogeneity across people with ADAD. Autosomal Dominant Alzheimer's Disease: A Pathophysiology Review discusses the history of ADAD and its cognitive, neuroimaging and biomarker trajectories. This book focuses how ADAD can provide a unique insight into genetically driven and sporadic forms of AD. Edited by Dr. Jasmeer Chhatwal and Dr. Eric McDade, and contributed by leading experts in the field, this book will be become the leading tool for researchers and clinicians in Alzheimer's Disease.

Contenu

1. Introduction 2. History of ADAD 3. Cognitive Trajectories in ADAD 4. Beyond Memory Loss: Non-Amnestic Manifestations of ADAD 5. Towards a Unified Framework in Sporadic and Genetically driven AD: Neuroimaging and Biomarker Trajectories in ADAD 6. Applying lessons from ADAD to sporadic AD 7. Mechanisms underlying ADAD mutations 8. Heterogeneity Across ADAD Genotypes 9. Lessons from AD in Down's Syndrome 10. Neuropathology of ADAD 11. ADAD Experimental Therapeutics