A History of Genomics across Species, Communities and Projects

This book is open access, which means that you have free and unlimited access Examines the history of genomics in a unique way, due to its wide chronological timeframe and multispecies approach Critically reinterprets the 'translational gap' between sequence data and their potential uses Highlights the significance of scientific communities that were eclipsed by the Human Genome Project

Auteur

Miguel García-Sancho is a Senior Lecturer at the University of Edinburgh in the UK. He led the project 'TRANSGENE: Medical Translation in the History of Modern Genomics', with funding from the European Research Council.

James Lowe is a Senior Research Fellow at the University of Edinburgh in the UK. He is a historian and philosopher of biology who worked on the European Research Council-funded project 'TRANSGENE: Medical Translation in the History of Modern Genomics'.

Résumé

"These new accounts of various genome projects, based on new interviews and archival work, should stand in their own right as important contributions to the history of sequencing. García-Sancho and Lowe frame these stories as contributions to an explicitly revisionist history of genomics. ... the book's revisionist argument hinges on an expansive definition of genomics that seeks to include a wide range of practices related to medicine and agriculture." (Hallam Stevens, Journal of the History of Biology, Vol. 57 (1), 2024)

Contenu
Chapter 1. Introduction.- Part I. The Diversity of Genomics.- Chapter 2. Distributed and Concentrated Strategies in the Sequencing of the Yeast Genome.- Chapter 3. The Human Genome Project(s).- Part II. Communities and Reference Genomes.- Chapter 4. The Funnelling Effect of the Sanger Institute.- Chapter 5. The Pig Community and Their Reference Genome.- Part III. Contextualising and Enhancing Reference Genomes.- Chapter 6. Making Reference Genomes Useful: Annotation.- Chapter 7. Improving and Going Beyond Reference Genomes.- Chapter 8. Conclusion.