Insights into Migraine Treatments

Auteur
Massimo Filippi, MD, is Full Professor of Neurology at Vita-Salute San Raffaele University, Director of the Residency School in Neurology, President of the Bacherlor's Degree in Physiotherapy, Chair of the Neurology and Neurorehabilitation Units, Director of the MS Center, Director of the Neurophysiology Service, and Director of the Neuroimaging Research Unit at IRCCS Scientific Institute San Raffaele, Milan. His research activity has always focused on the definition of the mechanisms underlying various neurological conditions, including multiple sclerosis, neurodegenerative disorders, and migraine. As Director of the of the Neuroimaging Research Unit, he coordinated the MRI acquisition and analysis of several large-scale international MRI-monitored trials of multiple sclerosis. He is member of various national and international Scientific Societies and Boards and for some of them, he holds or has held institutional roles. He is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain Mapping, Radiology, and Neurological Sciences. Roberta Messina, MD, PhD, is a neurologist with expertise in the evaluation of headache patients, as well as in the analysis of MRI. She is a post-doctoral researcher at the Neuroimaging Research Unit and a headache specialist at the Headache Center at IRCCS Scientific Institute San Raffaele, Milan. Her main interests are studying biomarkers of headache patients´ responses to treatments, and the use of MRI techniques in primary headache disorders. She has applied MRI techniques to study the mechanisms underlying migraine pathophysiology, yielding new insights into brain alterations associated with migraine. She has collaborated in national and international studies assessing the efficacy, safety, and mechanisms of actions of novel treatments employed for migraine prevention. She is the Italian representative in the Juniors Committee of the International Headache Society and part of its Education Committee. She is on the Editorial Board of the Journal of Headache and Pain.

Texte du rabat
Insights into Migraine Treatments: Towards Personalized Medicine provides knowledge to facilitate the choice of optimal treatment for each patient in the context of migraine care. It presents the numerous therapies to treat migraines, and the methods by which they function. Further, this book discusses the challenges of determining which option is best for a particular patient. It offers key information on efficacy, safety, and biomarkers of patient responses to currently available therapies, thereby providing a resource to help healthcare professionals choose treatments tailored to individual patients. Researchers and clinicians alike will benefit from its solution-driven perspective. Insights into Migraine Treatments: Towards Personalized Medicine discusses topics ranging from pathophysiology of migraines to acute treatments, pharmacological and non-pharmacological preventive treatments, neuroimaging and neurophysiology, all with a view toward meeting the unique needs of each migraine patient.

Contenu

1. Clinical manifestations of migraine
   
   2. Migraine pathophysiology
   3. Why, when and how to treat migraine patients?
   4. Acute treatments: NSAIDs, ergot alkaloids, triptans and ditans
   5. Acute treatments: neuromodulation and peripheral nerve blocks
   6. Oral preventive treatments: antidepressants, antihypertensives, anticonvulsants, beta blockers and calcium channel blockers
   7. Preventive treatments: Onabotulinumtoxin A and peripheral nerve blocks
   8. Non-pharmacological approaches in migraine prevention: neuromodulation, nutraceuticals and behavioral approaches
   9. Why to target the CGRP pathway?
   10. Gepants
   11. Anti-CGRP monoclonal antibodies
   12. Biomarkers of treatment response
   13. Migraine treatments: What have we learned from neuroimaging?
   14. Migraine treatments: What have we learned from neurophysiology?
   15. Treatments to use in special circumstances: children, pregnancy, elderly
   16. Unmet needs and future perspectives