Innovative Catalysis in Organic Synthesis

C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of
biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book.

Auteur
Pher G. Andersson holds a chair at the Department of Biochemistry and Organic Chemistry at Uppsala University, Sweden. He received his Ph.D. in 1991 and became a lecturer at Uppsala University in 1994 and a Professor in 1997. Among his many awards are the Bjurzons award (1992), the Oscar award (1995), the Junior Individual Grant for outstanding young researchers (1997), and the Astra Zeneca Research Award in Organic Chemistry (2004). He was Chairman of the management committee for the COST D24 program 'Sustainable Chemical Processes: Stereoselective Transition Metal-Catalyzed Reactions' which ran from 2001-2006 and he was the Coordinator for the 'Excellent Nordic Chemistry Network'. Since 2011 he also holds a position as Honorary Research Professor at UKZN, South Africa. Pher Andersson has authored more than 100 publications and edited the books 'Modern Reduction Methods' (Wiley-VCH, 2008) together with his former co-worker Ian Munslow and 'ridium Catalysis' (Springer, 2010). His research interests cover selective synthesis, asymmetric catalysis, and sustainable chemistry.

Contenu
FOREWORD PART I: Oxidation Reactions POLYOXOMETALATES AS HOMOGENEOUS OXIDATION CATALYSTS Soluble Metal Oxides as Oxidation Catalysts Homogeneous Oxidations with POMs Based Only on Mo(VI), W(VI), V(V) Addenda Ions Homogeneous Oxidations with TMS-POMs Conclusions BIOINSPIRED OXIDATIONS CATALYZED BY NONHEME IRON AND MANGANESE COMPLEXES Introduction Catalytic Oxidation of C = C Bonds by Nonheme Iron and Manganese Complexes Catalytic Oxidation of C - H Bonds by Nonheme Iron and Manganese Complexes THE FABULOUS DESTINY OF SULFENIC ACIDS Introduction Synthesis of Stable Sulfenic Acids Generation of Transient Sulfenic Acids Reactivity of Sulfenic Acids in the Preparation of Sulfoxides and Unsymmetrical Disulfides Synthesis of Stable Sulfenate Anions Generation of Transient Sulfenate Anions Leading to Sulfoxides Conclusions SUSTAINABLE CATALYTIC OXIDATIONS WITH PEROXIDES Introduction Metal-Based Selective Oxidations Biocatalytic Oxidations with Hydrogen Peroxide Conclusions PART II: Hydrogenation and Reduction Reactions ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES BY RH-CATALYSTS WITH CHIRAL MONODENTATE P-LIGANDS Introduction Chiral Monodentate Phosphorus Ligands in Asymmetric Hydrogenation Catalyst Precursors Mechanistic Insights Formation of the MAC Adducts Evolution of MAC-Adducts and Origin of Enantioselection RECENT ADVANCES IN THE SYNTHESIS AND CATALYTIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES AND BICYCLO[2.2.2]OCTENES Introduction Synthesis of DDAA Derivatives and Bicyclo[2.2.2]octenes Ligands Homogeneous Hydrogenation and Hydrogenolysis Reactions with Dehydroamino Acid Derivatives and Bicyclo[2.2.2]oct-7-enes over Nanocolloids-Modified Catalysts Heterogeneous Catalysts for Hydrogenolysis of Bicyclo[2.2.2]oct-7-enes Layered-Double Hydroxides as a Support for Rh(TPPTS)3 and Rh-(m-TPPTC)3 Homogeneous Catalysts Conclusions IR-CATALYZED HYDROGENATION OF MINIMALLY FUNCTIONALIZED OLEFINS USING PHOSPHITE - NITROGEN LIGANDS Introduction Application of Phosphite - Nitrogen Ligands Conclusions MODELING IN HOMOGENEOUS CATALYSIS: A TUTORIAL Introduction Molecular Modeling Wave Function Theory, WFT Density Functional Theory, DFT Orbitals Basis Sets Solvation Analyzing the Reaction Energies Analyzing the Electronic Structure PART III: C - C and C - Hetero bond-Forming Reactions GOLDEN TIMES FOR ALLENES Introduction Cyclization of Hydroxyallenes Cyclization of Aminoallenes Cyclization of Thioallenes Conclusion COPPER CATALYSIS IN ARENE AND HETEROARENE FUNCTIONALIZATION THROUGH C - H BOND ACTIVATION Introduction C - C Bond-Forming Reactions C - N Bond-Forming Reactions C - O Bond-Forming Reactions C - Halogen Bond-Forming Reactions LIGATED ORGANOCUPRATES: AN A - Z ROUTEMAP OF MECHANISM AND APPLICATION Introduction Accepted Mechanistic Proposals Selective Applications in Privileged Copper(I) Catalysis RH-, AG-, AND CU-CATALYZED C - N BOND FORMATION Introduction Historical Background Copper- and Silver-Catalyzed C - N Bond Formation Rhodium-Catalyzed C - N Bond Formation Conclusions DEVELOPMENT OF THE ASYMMETRIC NOZAKI - HIYAMA - KISHI REACTION Introduction Development of a Catalytic Nozaki - Hiyama - Kishi Reaction Catalytic Enantioselective Nozaki - Hiyama - Kishi Reaction Application of Salen-Derived Ligands in the Enantioselective Nozaki - Hiyama - Kishi Reaction Application of Oxazoline-Containing Ligands in the Catalytic Enantioselective Nozaki - Hiyama - Kishi Reaction Application of Tethered Bis(8-quinolinato) Chromium Complexes in the Catalytic Enantioselective Nozaki - Hiyama - Kishi Application of Chiral Spirocyclic Borate Ligands to the Catalytic Enantioselective Nozaki - Hiyama - Kishi Allylation Applications of Catalytic Nozaki - Hiyama - Kishi Reaction in Total Synthesis Conclusions CHIRAL IMIDATE LIGANDS: SYNTHESIS AND APPLICATIONS IN ASYMMETRIC CATALYSIS Introduction Cyclic Imidates Synthesis of Imidates Synthesis of Imidate Ligands Synthesis of Imidate - Copper (I) Complexes Application of Chiral Imidate Ligands in Enantioselective Catalysis Novel Synthetic Applications of Cyclic Imidates Conclusions CATALYZED ORGANIC REACTIONS IN BALL MILLS Introduction Acid- or Base-Catalyzed Reactions Organocatalytic Methods Metal-Catalyzed Reactions Conclusion and Perspective