Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes

The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria.

Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies. Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.

Compares the biogenesis, structure, and function of various type of mitochondria in distinct eukaryotic lineages Provides new a new perspective on mitochondria origin and the evolution of eukaryotic cells Investigates the constraints that led to the reduction of mitochondria in parasitic protists , furthering our understanding of the evolution of parasitism

Texte du rabat
"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes, 2nd edition" provides a comprehensive summary of the current knowledge on these organelles, which occur in unicellular, often parasitic organisms, including human pathogens. It discusses the discovery of these widely distributed organelles, as well as their evolution and recent advances in the study of their structure and function. The book also describes their properties, such as protein import, structure, metabolism and adaptation, their proteome and their role in drug activation and resistance.

The book will appeal to researchers and students interested in biology and medicine, and to those who are mainly interested in basic science-cell biology, parasitology, microbiology, evolution etc., but also to those interested in organelles as potential targets for chemotherapy.

Contenu
Chapter 1: Introduction.- Chapter 2: The evolution of oxygen independent energy metabolism in eukaryotes with hydrogenosomes and mitosomes.- Chapter 3: Protein Import into Hydrogenosomes and Mitosomes.- Chapter 4: Structure of the Hydrogenosome.- Chapter 5: Hydrogenosomes of Anaerobic Ciliates.- Chapter 6: Metabolism of Trichomonad Hydrogenosomes.- Chapter 7: Hydrogenosomes of Anaerobic Fungi: an Alternative Way to Adapt to Anaerobic Environments.- Chapter 8: The proteome of T. vaginalis hydrogenosomes.- Chapter 9: Mitosomes in parasitic protists.- Chapter 10: The Mitochondrion-Related Organelles of Crypto-sporidium species.- Chapter 11: The Mitochondrion-Related Organelles of Blastocystis.- Chapter 12: Mitochondrion-related organelles in free-living protists.- Chapter 13: Protists without mitochondria, how it may happen?.