Neurotransmitters and Epilepsy

The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotransmitter systems in various experimental models of epilep sy. Toward this goal we have included in this book chapters on neurotransmitter systems in nine different epilepsy models. To com plete the coverage of this topic, there is a chapter on the role of selected neurotransmitters in the various types of human epilep sies. In the final chapter the editors integrated the neurotransmit ter data from the various epilepsy models into a matrix from which a better understanding of the function of these neurotransmitters in modulating epileptogenesis may be obtained. The information found in this book is not the result of a sym posium on this topic, but rather a review of available information on neurotransmitters in each of the experimental models. The evi dence is presented by knowledgeable researchers using these models. This approach gives a current, broader, and more thorough presentation of each of the topics. We therefore feel that this is not just a glimpse at the subject matter, but a panoramic view of the topic.

Contenu
Neurotransmitter Systems and Epilepsy: An Overview.- Epilepsy-Prone Mice: Genetically Determined Sound-Induced Seizures.- The Spontaneously Epileptic Mongolian Gerbil.- The Genetically Epilepsy-Prone Rat.- The Epileptic Chickens.- Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model.- In Vitro Models of Epilepsy.- Experimental Epilepsy Induced by Direct Topical Placement of Chemical Agents on the Cerebral Cortex.- Seizures Induced by Convulsant Drugs.- The Role of Neurotransmitters in Electroshock Seizure Models.- Neurotransmitters in Human Epilepsy.- Neurotransmitter Systems and the Epilepsy Models: Distinguishing Features and Unifying Principles.