Age-Structured Population Dynamics in Demography and Epidemiology

This book is the first one in which basic demographic models are rigorously formulated by using modern age-structured population dynamics, extended to study real-world population problems. Age structure is a crucial factor in understanding population phenomena, and the essential ideas in demography and epidemiology cannot be understood without mathematical formulation; therefore, this book gives readers a robust mathematical introduction to human population studies. In the first part of the volume, classical demographic models such as the stable population model and its linear extensions, density-dependent nonlinear models, and pair-formation models are formulated by the McKendrick partial differential equation and are analyzed from a dynamical system point of view. In the second part, mathematical models for infectious diseases spreading at the population level are examined by using nonlinear differential equations and a renewal equation. Since an epidemic can be seen as a nonlinear renewal process of an infected population, this book will provide a natural unification point of view for demography and epidemiology. The well-known epidemic threshold principle is formulated by the basic reproduction number, which is also a most important key index in demography. The author develops a universal theory of the basic reproduction number in heterogeneous environments. By introducing the host age structure, epidemic models are developed into more realistic demographic formulations, which are essentially needed to attack urgent epidemiological control problems in the real world.

Is the first attempt to give a comprehensive, rigorous formulation of the basic demographic models Analyzes structured epidemic models from the demographic point of view as the renewal process of individuals, providing a unified perspective for this research field Provides an appendix containing the universal theory of the basic reproduction number with its extensions, which is a common key idea in demography and epidemiology Includes supplementary material: sn.pub/extras

Auteur
Hisashi Inaba, Professor, Graduate School of Mathematical Sciences, The University of Tokyo, 3-8-1 Komaba Meguro-ku Tokyo 153-8914 Japaninaba@ms.u-tokyo.ac.jp

Contenu

1 The Stable Population Model.- 2 Extensions of the Linear Theory.- 3 Nonlinear One-Sex Models.- 4 Pair Formation Models.- 5 Basic Ideas in Epidemic Modeling.- 6 Age-Structured SIR Epidemic Model.- 7 Epidemic Models for HIV Infection.- 8 Variable Susceptibility, Reinfection and Immunity.- 9 Basic Reproduction Number R 0.- 10 Mathematical Tools.