Genome Chaos

Auteur

Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng's group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.

Texte du rabat

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance, and represents a clear unit of selection for macroevolution. Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. This new edition fully embraces the integration of system information with genome-mediated evolutionary mechanisms and supports this framework with recent findings and research.

Ten evidence-based chapters discuss 4D genomics, genes, and genomes as distinct biological entities, genome chaos, macrocellular evolution, karyotype coding, and fuzzy inheritance, as well as an entirely novel information flow-driven model of evolution, and more. All new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary theory. This synthesis offers an updated evolutionary theory, unifying physical, chemical, and biological mechanisms within organismal systems, and details the evolution of information packages where information flow, matter arrangement, and energy interact.

Contenu

1. From Mendelian Genetics to 4D Genomics. No significant changes; adding new references 2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Cellular Macroevolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer. Replace four Figures with modifications 4. Karyotype Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity 5. Why Sex? Genome Reinterpretation Dethrones the Queen 6. Breaking the Genome Constraint: The Mechanism of Macroevolution 7. The Creation and Maintenance of System Information for Complexity and Biodiversity 8. Searching for an Information-Based and Historically Contingent Evolutionary Theory 9. The Genome Architecture Theory: A New Framework 10. The Rationale and Challenges for Molecular Medicine