New Drug Development for Known and Emerging Viruses

Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades
Written by leading medicinal chemists and virologists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronavirus-2 causing the present pandemic.
'New Drug Development for Known and Emerging Viruses' describes the discovery and development process of antiviral agents for different species of viruses and their targets based on the experiences from seven human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HCMV, and HSV). It covers the properties and potential of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses.

• Covers the entire field of antiviral drug discovery and development
• Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2
• Summarizes the successes of the past years in developing ground-breaking medicines against 7 major human viruses, both from the medicinal chemistry and the pharmacological angle
• Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues
  'New Drug Development for Known and Emerging Viruses' is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Auteur
Helga Rübsamen-Schaeff, PhD, is founding CEO of AiCuris and the chair of AiCuris' Scientific Advisory Board. Before founding AiCuris she served at Bayer as SVP and Head of Infectious Disease Research. Before that time, she was Scientific and Managing Director of the Georg-Speyer-Haus in Frankfurt. A chemist by training, Professor Rübsamen-Schaeff has been professor of biochemistry at the University of Frankfurt since 1988. Her research interests focus on research and development of antiviral drugs, novel resistance-breaking antibiotics, emerging infectious diseases and oncology. Prevymis, a drug against HCMV discovered under her direction has reached the market.

Helmut Buschmann, PhD, has over 25 years of international experience in drug discovery research and drug development in the pharmaceutical/biotechnology sectors in different therapeutic areas, from pain research to anti-infectives. Currently, he is Head of Chemistry, Pharmaceutical Development and Patent Affairs at AiCuris and cofounder and co-owner of RD&C Research, Development & Consulting in Vienna.

Contenu
HIV - Disease overview, targets for therapy and open issues
Curing Hepatitis C with Direct-Acting Antiviral Therapy
Antiviral Drugs against Influenza Virus
Respiratory Syncytial Virus Immunoreactivity, Vaccine development, and Therapeutics
Herpes simplex viruses
Antiviral strategies against the Human Cytomegalo Virus: Inhibitors of Viral Terminase
Antiviral targeting of the complex Epstein Barr virus life cycle
Kaposi's Sarcoma-associated Herpesvirus - antiviral treatment
Hepatitis B virus: HBV capsid assembly modulators (CAMs)
Hepatitis E virus - Current development in antiviral strategies
Antiviral Therapy of Adenovirus Infections
New Developments in Antiviral Drugs against ssDNA-Viruses: Human Parvovirus Infection
Antiviral targets and strategies to treat and prevent human norovirus infections
Antiviral strategies against (non-polio) picornaviruses
Novel antiviral strategies against emerging arbovirus infections
Current Therapies for Biosafety Level 4 Pathogens
Antiviral Strategies Against Coronaviruses