Concepts and Models in Bioinorganic Chemistry

This didactic textbook provides a brief background on relevant biological systems and describes their structural, functional and spectroscopic results, while summarizing key developments and compounds in the respective model systems.

Das künftige Standardwerk! Endlich ein didaktisch sinnvoll aufgebautes Lehrbuch, das sich in aller Ausführlichkeit der Rolle von Modellsystemen in der bioanorganischen Chemie widmet. Zu den Themen des ersten Teils zählen unter anderem Mechanismen des Elektronentransfers, Bioorganometallverbindungen und Metall-DNA-Komplexe, im zweiten Teil steht die anorganische Chemie mit Metalloenzymen im Mittelpunkt. Unter Federführung der erfahrenen Herausgeber stellen Ihnen Fachleute der jeweiligen Gebiete relevante biologische Systeme mit ihren strukturellen, funktionellen und spektroskopischen Eigenschaften vor. Zur besseren Übersicht sind alle Kapitel gleich strukturiert; nach einem historischen Abriss folgt jeweils eine Tabelle mit den wichtigsten Enzymen. Am Ende der einzelnen Beiträge fassen die Autoren die Kernpunkte zusammen und sammeln offene Fragen zu den besprochenen Systemen. Für fortgeschrittene Studenten und Doktoranden in der Chemie und Biochemie, den Lebenswissenschaften und verwandten Gebieten.

Auteur
Heinz-Bernhard Kraatz obtained his Ph.D. from the University of Calgary in 1993 (inorganic chemistry, with P. M. Boorman). After a shorter stay at the University of Maryland, he spent two years at the Weizmann Institute as a Minerva postdoctoral fellow (1994-1995). He was a Research associate at the National Research Council of Canada (1996-1997). In 1998 he was appointed to the University of Saskatchewan, where he was Associate Professor since 2001 and became full Professor in 2006. HBK is the Canada Reseach Chair in Biomaterials. He received several awards and was the organizer of meetings in bioinorganic chemistry and electrochemistry in Canada. Research in his group focusses on the design of peptides and surface-supported peptide assemblies modified by inorganic and organometallic moieties to study electron transfer and to develop new biosensors. Nils Metzler-Nolte (né Metzler) obtained his Ph.D. from the University of Munich in 1994 (Organoboron chemistry, with H. Nöth). After a postdoctoral year with M. L. H. Green in Oxford, he started independent research at the Max-Planck-Institut für Strahlenchemie (now MPI for Bioinorganic Chemistry). He obtained his Habilitation at the University of Bochum in May 2000 and was soonafter appointed Professor for bioinorganic chemistry at the University of Heidelberg. In 2006, he accepted a Chair for Inorganic Chemistry at the University of Bochum. His work has been recognized by several awards and he has organized national and international conferences in bioorganometallic chemistry. His research interest is in bioorganometallic chemistry and functional bioconjugates with transition metals, including aspects of medicinal inorganic chemistry.

Contenu
The Biodistribution of Metal Ions Medicinal Inorganic Chemistry The Chemical Toxicology of Metals and Metalloids Theoretical Modeling of Redox Processes in Enzymes and Biomimetic Systems Charge Transport in Biological Molecules Bioorganometallic Chemistry The Bioinorganic Side of Nucleic Acid Chemistry: Interactions with Metal Ions Nuclease and Peptidase Models Metalloporphyrins, Metalloporphyrinoids, and Model Systems Model Complexes for Vanadium-Containing Enzymes Model Complexes for Molybdenum- and Tungsten-Containing Enzymes Structural and Functional Models for Oxygen-Activating Nonheme Iron Enzymes Model Chemistry of the Iron-Sulfur Protein Active Sites Model Complexes of Ni-Containing Enzymes Hydrogenases and Model Complexes Model Complexes for Copper-Containing Enzymes Model Complexes for Zinc-Containing Enzymes