Health Impacts of Developmental Exposure to Environmental Chemicals

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children's environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines furtherresearch directions and related policymaking aspects.

Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children's health can be affected by harmful chemicals and other environmental toxicants.

Presents concise and cutting-edge studies on how exposure to environmental chemicals can affect human health and development, including the burgeoning DOHaD concept Provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children's environmental health research Puts forward ideas on how to bridge the gap between research evidence and policymaking

Auteur

Reiko Kishi

Center for Environmental and Health Sciences

Hokkaido University

Sapporo

Hokkaido, Japan

Philippe Grandjean

Harvard T.H. Chan School of Public Health

Department of Environmental Health

Boston

Massachusetts, USA

University of Southern Denmark

Department of Environmental Medicine

Denmark

Contenu

Part 1 Introduction.- 1 Impacts of developmental exposure to environmental chemicals on human health with global perspectives.- Part 2 Adverse health effects on human developing organs caused by environmental chemicals-the role that chemicals might play.- 2 Environmental exposures and adverse pregnancy-related outcomes.- 3 Effects of Environmental Chemical Exposure on Birth Defects (Except Cryptorchidism and Hypospadias).- 4 Cryptorchidism and hypospadias.- 5 Endocrine-distributing chemicals and reproductive function.- 6 Thyroid hormone system and development.- 7 Neurodevelopment and Neurobehavioral disorders in relation to developmental exposures.- 8 Immunotoxicity: Impacts and research approaches.- 9 Long-Term Implications of Developmental Programming and Obesity.- Part 3 Impact of Environmental Chemical Hazards on human development.- 10 Impact of Air Pollution Hazards on Human Development.- 11 Mercury, Lead, Manganese and Hazardous Metals.- 12 Environmental Pollution and Recent Data on Asian Children's Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides.- 13 Effects of Developmental Exposure to Perfluoroalkyl Substances on Health Outcomes in Pregnant Women and Offspring.- 14 Brominated flame retardants (BFRs).- 15 Exposure to phthalate acid esters and the its health effects.- 16 Bisphenols and alkylphenols.- Part 4 Important aspects of research for prevention and strategy.- 17 Adverse Outcome Pathways for Developmental Toxicity.- 18 Exposomics-The Exposome in Early Life.- 19 Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.- 20 Epigenetics Strategies for Prevention Research.- 21 From research to intervention.- Part 5 Closing.- 22 Further direction of research and policy making of environment and children's health.