Growth Factors, Peptides, and Receptors

The Twelfth Annual Washington Spring Symposium on Health Sciences attracted over 300 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington, D.C. during June 1-5, 1992. The theme of the meeting was "Growth Factors, Peptides, and Receptors," and speakers emphasized both basic and clinical research in these areas. The seven plenary sessions emphasized Peptides, Growth Factors, Peptide Receptors, Growth Factor Receptors, Second Messengers, Proliferation, and Clinical Correlations. The chapters in this volume are derived from each of these scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist Award was presented to Dr. Solomon H. Snyder for his numerous contributions to the field of neurochemistry. He presented the keynote address "Nitric Oxide: A Novel Neuronal Messenger." Dr. Snyder discussed the pathway of nitric oxide (NO) synthesis by the enzyme NO synthase. Released NO may be responsible for the neuronal toxicity associated with NMDA, an excitatory amino acid analogue. Dr. Snyder noted that NO may be the first of a new class of transmitters, with carbon monoxide being another candidate. The Distinguished Public Service Award was presented to Senator Fritz Hollings in of his leadership and outstanding achievements in the United States Senate recognition and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Hollings stressed the need for continued support of research to combat serious diseases such as cancer.

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Proceedings of the XIIth Washington International Spring Symposium at George Washington University held in Washington, D.C., June 1-5, 1992

Contenu
IPeptides.- 1. Distribution of Endothelin, a Putative Growth Promoting Peptide, Using Modern Microscopical Imaging Methods.- 2. Vasoactive Intestinal Peptide: From Molecular Genetics to Neurotropism.- 3. Design and Structure/Conformation-Activity Studies of a Prototypic Corticotropin-Releasing Factor (CRF) Antagonist: Multiple Alanine Substitutions of CRF12-41.- 4. Retinoic Acid Regulates preproVIP Expression in the Human Neuroblastoma Cell Line NB-1.- 5. Structure-Dependent Inhibitory Effect of Galanin on Insulin, Gastric Acid and Pancreatic Amylase Secretion in Rat.- 6. Amphibian Opioids: Novel Dermorphin-like Peptides.- 7. Proteases for Neuropeptide Precursor Processing in Bovine Adrenal Medullary Chromaffin Granules.- 8. Amylin and Neuromedin U: Two Novel Regulatory Peptides of the Gastroenteropancreatic System.- IIGrowth Factors.- 9. Gene Transfer into the Central Nervous System: Neurotrophic Factors.- 10. The Structural and Biological Properties of Heparin-Binding EGF-like Growth Factor.- 11. Structural Organization of the Multiple Transforming Growth Factor ? Genes.- 12. Dexamethasone Modulates the Response of Rat Stromal Bone Marrow Derived Bone-like Cells to bFGF and IGF-I.- 13. Behavioral, Hormonal and Neurochemical Alterations in Transgenic Mice Overexpressing Transforming Growth Factor ?.- 14. Growth Factors and Brain Injury.- 15. The Basic Fibroblast Growth Factor Isoforms: Endogenous and Exogenous Behavior.- IIIPeptide Receptors.- 16. Structural Analysis of Ligand Binding Characteristics for the Bombesin/Gastrin Releasing Peptide Receptor.- 17. Identification of Zeta Opioid Receptor Binding Polypeptides in Rat Cerebellum.- 18. Identification and Characterization of Somatostatin, Gastrin Releasing Peptide, and Neuromedin B Receptors onEstablished Tumors and Tumor Cell Lines.- 19. Neuropeptide Receptor Sub-types: Neuropeptide Y and Calcitonin-Gene Related Peptides as New Examples.- 20. Vasoactive Intestinal Peptide and Astrocyte Mitogenesis: In Vitro and In Vivo Studies.- 21. Synthesis and Biological Activity of Cholecystokinin Antagonists.- 22. Peptide-Neuromedin B Receptor Interactions: Comparison with Gastrin Releasing Peptide Receptor Interactions.- IVGrowth Factor Receptors.- 23. Neurotrophins in the Adult Brain: Effects on Hippocampal Cholinergie Function Following Deafferentation and Regulation of Their Expression by Pharmacological Agents and Lesions.- 24. Angiosuppressive and Antiproliferative Actions of Suramin: A Growth Factor Antagonist.- 25. [125I]IGF-I, [125I]IGF-lI, and [125I]Insulin Receptor Binding Sites in the Rat Hippocampal Formation: Topographic Distribution and Response to Entorhinal Ablation.- 26. Estrogen Regulation of the Pituitary Insulin-like Growth Factor System.- 27. Effects of Radiofrequency Radiation on Growth Factor Receptors.- 28. Structure-Function Analysis of Fibroblast Growth Factor-1 (Acidic Fibroblast Growth Factor).- VSecond Messengers.- 29. MDGF-1: A New Tyrosine Kinase-Associated Growth Factor.- 30. Interleukin-11 Mediated Signal Transduction Pathways: Comparison with Those of Interleukin-6.- 31. Regulation of a Membrane Tyrosine Phosphatase by Somatostatin.- 32. Cycloheximide Has Differing Effects on Immediate Early Gene Expression in IL-3 or M-CSF Stimulated Human Monocytes.- 33. Regulation of Gastrin Releasing Peptide Gene Expression.- VIProliferation.- 34. TGF? Induced Proliferative Changes in Transgenic Mice.- 35. Somatostatin and Human Gastrointestinal Cancer.- 36. Inhibition by GnRH Antagonists of Breast and Endometrial Cancer Cell GrowthInduced by Estrogen and Insulin-like Growth Factors.- 37. ?-Endorphin Is Metabolized in Vitro by Human Small Cell Lung Cancer to ?-Endorphin Which Stimulates Clonal Growth.- 38. The Role of EGF and Its Receptors in the Growth of Human Gastric Carcinoma Cell Line (MGC80): Evidence for an Autocrine Mechanism.- 39. The Single-Chain Immunotoxins BR96 sFv-PE40 and BR96 sFv-PE38: Potent Anti-tumor Agents for the Treatment of Human Cancer.- VIIClinical Correlations.- 40. Hematopoietic Cytokines to Support Repeated Doses of Dose-Intensive Chemotherapy with Cyclophosphamide, Etoposide, and Cisplatin (DICEP).- 41. Interleukin-2 (IL-2) Augments the Expression of Transforming Growth Factor Beta in Patients with Disseminated Cancer.- 42. Peptide Signals for Satiety.- 43. The Role of Somatostatin Receptors in the Diagnosis and Therapy of Cancer.