Supercritical Fluids in Pharmaceutical and Biomedical Technologies

Auteur
Giovanna Della Porta is Professor of Pharmaceutical Chemistry and Drug Delivery at the Department of Medicine, Surgery and Dentistry of the University of Salerno in Italy; she is Head of the Translational Medicine Lab@UNISA focused on the development of innovative drug delivery formulation and tissue engineering research applied to the regenerative medicine of musculoskeletal tissues.

Texte du rabat

Supercritical Fluids in Pharmaceutical and Biomedical Technologies: From Controlled Drug Release Formulation describes the well-studied, but previously not well summarised supercritical fluid technologies useful for pharmaceutical and biomedical applications. Supercritical technologies have been described over the last 20 years as innovative and capable of solving many problems relating to conventional chemical processes such as extraction, crystallization, foaming, drying precipitation, aerogels fabrications. This is generally true but there remain exceptions and limitations. Featuring extensive case studies and examples presenting from lab-scale to industrial scale, the author highlights the innovations of the described processes, but also their drawbacks, such as the difficulties to generalize the process application to several drugs and biomolecules. The book provides a critical overview on the necessity of process optimization case-by case that have limited the use of these dense gases in larger scale pharmaceutical or biomedical industrial production. Supercritical Fluids in Pharmaceutical and Biomedical Technologies: From Controlled Drug Release Formulation to Tissue Engineering will appeal to graduate and postdoc level students and researchers primarily in chemistry, pharmaceutical chemistry, and chemical engineering. R&D scientists at pharma and biotech companies and postdoc students studying advanced pharmaceutical technologies for drug delivery and tissue engineering, medical biomedical technology and bioengineering will also find the book useful for reference.

Contenu

1. Dense gases and supercritical fluids from thermodynamic to fluidodynamics
   
   2. High pressure technology and related features
   3. Drug delivery device fabrication by supercritical carbon dioxide technologies: biopolymer micro/nano carriers
   4. Drug delivery device fabrication by supercritical carbon dioxide technologies: liposomes, nanovescicles, niosomes, and polymersomes
   5. Scaffold for tissue engineering fabricated by supercritical carbon dioxide technologies: the challenge and the limitations of live cells culture and in vitro studies
   6. 3D microenvironments for tissue engineering and supercritical carbon dioxide technologies: potentials and drawbacks
   7. Examples and case studies
   8. Future perspectives and challenges