Gestational Trophoblastic Disease

This book offers a comprehensive presentation of histological diagnosis and differential diagnoses of Gestational Trophoblastic Disease (GTD). It provides in-depth reviews of the molecular genetic background of GTD, epidemiology and risk factors.

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

Contenu

Forward.- Preface and Dedication.- Gestational Trophoblastic Disease: General Aspects.- Developmental Biology of the Placenta.- Genetic Basis of Gestational Trophoblastic Disease.- Complete hydatidiform mole.- Partial hydatidiform mole.- Placental site trophoblastic tumor (PSTT).- Epithelioid trophoblastic tumor.-Gestational choriocarcinoma.- Persistent gestational trophoblastic neoplasia.- Tumor-like trophoblastic conditions.- Molecular Diagnosis of Gestational Trophoblastic Disease.- Clinical aspects of gestational trophoblastic disease.- Appendix. <p