Germ Cell Development, Division, Disruption and Death

This book is composed of chapters prepared by invited speakers of the XIVth North American Testis Workshop, held in Baltimore, Maryland, February 19 to 22, 1997. The book reflects the desire of the Testis Workshop Scientific Commit tee for a program addressing a broad array of current research focused on the germ cell, from its development through its death. Consequently, the research of those who have contributed chapters to this book addresses, or can be applied to, the hormonal and molecular regulation of spermatogonial cell development and nmc tion (Nishimune, Orth, Russell, Dym), meiosis (Bickel, Wolgemuth, Handel, Trasler), spermatogenesis (Sassone-Corsi, Habener, Braun), cell death and aging (Campisi, Chen, Knudson, Swerdloff), and toxicant effects on spermatogenesis (Sharpe, Keice, Robaire, Meistrich). In their preface to the proceedings of the 1988 Testis Workshop, Drs. Larry Ewing and Bernard Robaire noted that the first published description of semi niferous tubules in the testis was in 1668, by C. Aubry, and that "the exciting papers in these proceedings [of the 1988 Workshop] emphasize the significant progress that has been made since the mid-17th century in understanding testis and function. " It is quite clear that current research is proceeding at a breathtaking pace, with enormous strides having been made even since the XIIIth Workshop in 1995. If the XIVth Workshop succeeded, and this book succeeds, in convey ing this excitement in our field (which, of course, was our intent), credit belongs to the creativity of the Scientific Committee, whose members were William J.

Contenu
I. Spermatogonial Cell Development, Function, and Regulation.- 1. Cloning and Characterization of Genes Specifically Expressed in Germ Line Cells.- 2. Gonocyte-Sertoli Cell Interactions in Testes of Neonatal Rats.- 3. Spermatogonial Transplantation.- 4. Telomerase Activity Is Lost During Male Germ Cell Differentiation.- II. Meiosis.- 5. Regulation of Sister-Chromatid Cohesion During Drosophila Meiosis.- 6. Role of Cell-Cycle Genes in the Regulation of Mammalian Meiosis.- 7. Acquisition of Competence to Enter Meiotic Metaphase During Mammalian Spermatogenesis.- 8. Regulated Synthesis and Role of DNA Methyltransferase During Meiosis.- III. Molecular Regulation of Spermatogenesis.- 9. CREM: A Master-Switch Governing Transcription in Male Germ Cells.- 10. Expression of Activator and Repressor Isoforms of Transcription Factor CREB During Spermatogenesis.- 11. Repression and Activation of Protamine mRN A Translation During Murine Spermatogenesis.- IV. Regulation of Cell Death/Aging.- 12. Cell Senescence and Aging.- 13. Testicular Aging: Leydig Cells and Spermatogenesis.- 14. Molecular Regulation of Testicular Cell Death.- 15. Hormonal Regulation of Germ Cell Apoptosis.- V. Toxicant Effects on Spermatogenesis.- 16. Estrogen Effects on Development and Function of the Testis.- 17. Developmental Effects and Molecular Mechanisms of Environmental Antiandrogens.- 18. Targets of Chemotherapeutic Drug Action in Testis and Epididymis.- 19. Hormonal Protection of Spermatogenic Stem Cells Against Cytotoxic Agents.- Author Index.