Genome Analysis

Auteur
Dr. Dev Bukhsh Singh is currently an Assistant Professor in the Department of Biotechnology at Siddharth University, Kapilvastu, Siddharth Nagar, India since 2021. He also served as Assistant Professor in the Department of Biotechnology at Chhatrapati Shahu Ji Maharaj University, Kanpur, India from 2009-2021. He received BSc (Biology) and MSc from the University of Allahabad, an MTech from the Indian Institute of Information Technology, Prayagraj India, and a PhD in Biotechnology from Gautam Buddha University, India. He has been actively involved in teaching BSc and MSc Biotechnology students since 2009. His areas of research are medicinal biology, lead compound search, and drug design. He published three edited books: Frontiers in Protein Structure, Function, and Dynamics Computer-Aided Drug Design and Bioinformatics: Methods and Applications. He is a member of various national and international academic bodies and is a reviewer for several international journals. Prof. Timir Tripathi is a Professor of Molecular Biology in the Department of Zoology, School of Life Sciences, North-Eastern Hill University, Shillong, India. Earlier, he served as the Regional Director of Indira Gandhi National Open University, Kohima, Nagaland (2022-2023), where he contributed significantly to educational leadership, governance, and management. Before this, he was Senior Assistant Professor and Principal Investigator at the Department of Biochemistry, NEHU, Shillong (2009-2022). He holds a Ph.D. from Jawaharlal Nehru University, New Delhi, while working at the Central Drug Research Institute, Lucknow. He was a visiting faculty at ICGEB, New Delhi, India, and Khon Kaen University, Thailand. His research interests lie in the field of protein-substrate interaction and dynamics and understanding the roles of non-catalytic domains in regulating the catalytic activity of proteins. His primary focus is studying the conformational dynamics, interaction, and stabilization of the complexes formed by intrinsically disordered neuropathological protein aggregates, their properties of liquid-liquid phase separation, interaction, and roles in nucleocytoplasmic transport in neurodegenerative diseases. In addition, he is interested in analyzing the structural and functional characteristics of drug target proteins from the helminth liver fluke parasite Fasciola gigantica to identify new therapeutic strategies. He has received several national and international awards. He is an Associate Fellow of the Indian National Science Academy, New Delhi, and an elected member of the National Academy of Sciences, India, the Royal Society of Chemistry, and the Royal Society of Biology, UK. He has handled several research grants as a principal investigator from various national and international funding agencies. He has published over 100 research papers, reviews, commentaries, viewpoints, outlooks, and editorial articles in international journals, and has contributed several book chapters. He has edited six books and authored two textbooks for undergraduate and postgraduate students. Currently, he serves as the editor of the International Journal of Biological Macromolecules (Elsevier), senior editor of Critical Insights in Biophysics (Taylor & Francis), and is a member of the editorial boards of Scientific Reports and Acta Tropica.

Texte du rabat

Genome Analysis: Principles and Methods provides recent and advanced information about genome analysis approaches and techniques to study and annotate the structure and function of the genome. It is a compendium of important topics such as NGS analysis, genome fragmentation and assembly, metagenomics, cloning and expression, physical marker analysis, transcriptome data analysis, sequence alignment and comparison, evolutionary analysis, SNP analysis, genome-based disease diagnosis and therapies, micro-RNAs, pharmacogenomics, genetic approaches to disease intervention, and challenges with opportunities in genome analysis and genomics, etc. The latest developments in the field are discussed, and key concepts are introduced to ensure readers understand advanced concepts and methodologies in the area. The book serves as a valuable guide to the present, emerging, and evolving research methodologies in the field.

Contenu

1. Introduction to Genome Analysis and Genomics Approaches 2. Genome Complexity and Genome Organization 3. Databases for Genome and Genomic Information 4. Recent Techniques and Strategies for Large-Scale Sequencing 5. Techniques for NGS Data Analysis 6. Genome Fragmentation and Separation Strategies 7. Gene Cloning and Expression Systems 8. Physical Markers and Related Techniques for Marker Development 9. Gene Expression Analysis 10. Computational Approaches for Transcriptome Data Analysis 11. Metagenomics Approaches 12. Sequence Alignment and Comparison Tools 13. Approaches and Tools for Evolutionary Analysis 14. Gene Prediction Approaches 15. SNP Analysis and Related Genetic Disorders 16. Genome Annotation approaches 17. Genome Sequencing Projects and Major Outcomes 18. Human Genome Project and Current Status 19. Comparative Genomics and related Approaches 20. Micro-RNA Prediction Tools and Target Analysis 21. Pharmacogenomics: Current Status and Future Strategies 22. Mechanisms for Genetic Variations 23. Approaches for Genome-based Disease Diagnosis 24. Genetic Approaches to Disease Intervention 25. Challenges and Opportunities in Genome and Genomics Analysis