Functional and Structural Proteomics of Glycoproteins

This book assesses the emerging field of glycoproteomics and reviews progress in the study of glycoproteins, including in silico methods, high throughput separation and detection techniques for characterization of glycoproteins in cells and tissues.

It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

Covers a broad range of technologies Comprehensive articles written by international experts in the field of glycoproteomics A timely review of glycoproteins and methods for the diagnosis and treatment of glycoprotein related human diseases

Contenu
Preface.- Glycoproteomics in Health and Disease, W.B. Struwe et al..- Glyco-engineering of Fc Glycans to the Biological Functions in Therapeutic IgGs, T. Shantra Raju et al..- Bioinformatics Databases and Applications Available for Glycobiology and Glycomics, R. Ranzinger et al..- Lectin Microarrays: simple tools for the analysis of complex glycans, L. Krishnamoorthy and L.K. Mahal.- The Application of High Throughput Mass Spectrometry to the Analysis of Glycoproteins, S. Singh et al..- Solutions to the Glycosylation Problem for Low- and High-Throughput Structural Glycoproteomics, S.J. Davis and M. Crispin.- Role of Glycoproteins in Virus-Human Cell Interactions, T.A. Bowden and E.E. Fry.- Subject Index