Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès Dans La Chimie Des Substances Organiques Naturelles

During the past three decades the organic chemist has become in creasingly used to take advantage of more and more complex instrumenta tion and physical measurements in lieu of laborious, time-consuming and often ambiguous chemical transformations. Mass spectrometry is perhaps the most recent, most complex and most expensive addition to this field. In view of the astonishingly quick acceptance of nuclear magnetic reso nance by the organic chemist it is, in retrospect, surprising that he has neglected mass spectrometry for such a long time. This can be explained, in part, by the complexity of the instrumentation and some technical shortcomings of the earlier commercially available instruments but, to an even greater extent, it reflects also the prejudices against a technique that was originally mainly used for quantitative gas analysis. The usefulness of mass spectrometry as a qualitative technique in organic chemistry rather than a tool for quantitative analysis was more and more recognized towards the end of the last decade. A rather spectacular development followed during the intervening few years to the point that now any reasonably well equipped modern organic laboratory is supplied with, or at least has access to, one or more mass spectrometers suitable for work on organic compounds. Within the realm of organic chemistry the technique has become much more important, if not indispensable, for the natural products chemist while its application to synthetic problems is much less pro nounced.

Texte du rabat

During the past three decades the organic chemist has become in­ creasingly used to take advantage of more and more complex instrumenta­ tion and physical measurements in lieu of laborious, time-consuming and often ambiguous chemical transformations. Mass spectrometry is perhaps the most recent, most complex and most expensive addition to this field. In view of the astonishingly quick acceptance of nuclear magnetic reso­ nance by the organic chemist it is, in retrospect, surprising that he has neglected mass spectrometry for such a long time. This can be explained, in part, by the complexity of the instrumentation and some technical shortcomings of the earlier commercially available instruments but, to an even greater extent, it reflects also the prejudices against a technique that was originally mainly used for quantitative gas analysis. The usefulness of mass spectrometry as a qualitative technique in organic chemistry rather than a tool for quantitative analysis was more and more recognized towards the end of the last decade. A rather spectacular development followed during the intervening few years to the point that now any reasonably well equipped modern organic laboratory is supplied with, or at least has access to, one or more mass spectrometers suitable for work on organic compounds. Within the realm of organic chemistry the technique has become much more important, if not indispensable, for the natural products chemist while its application to synthetic problems is much less pro­ nounced.

Contenu
Table des matières.- Mass Spectrometry of Selected Natural Products.- I. Introduction.- II. Indole Alkaloids.- III. Tetrahydroisoquinoline Alkaloids.- IV. Bisbenzyl-tetrahydroisoquinoline Alkaloids.- V. Polycyclic Tetrahydroisoquinoline Alkaloids.- VI. Miscellaneous Alkaloids and Other Nitrogen Containing Natural Products.- VII. Quarternary Bases.- VIII. Natural Products Other than Alkaloids.- IX. High Resolution Mass Spectrometry.- References.- Pflanzliche Steroide mit 21 Kohlenstoffatomen.- I. Einleitung.- II. N-freie Pregnanderivate aus Scrophulariaceen.- III. N-freie Pregnanderivate der Asclepiadaceen.- IV. N-freie Pregnanderivate aus Apocynaceen.- V. N-haltige Pregnanderivate aus Apocynaceen.- VI. Pregnenolon als biogenetische Vorstufe für Digitanole, Cardenolide, Bufadienolide und Aminopregnan-derivate.- Cyelite: Biosynthese, Stoffwechsel und Vorkommen.- I. Einleitung.- II. Nomenklatur der Cyclite.- III. Biosynthese.- IV. Katabolischer Stoffwechsel.- V. Vorkommen der Cyclite.- VI. Tabellen.- The Chemistry of the Order Cupressales.- I. Introduction.- II. Botanical Classification of the Order Cupressales.- III. Chemical Constituents of Cupressales.- IV. Some Chemotaxonomic Aspects.- V. Chemical Constituents of Cupressales Species.- VI. Tables.- References.- Quinone Methides in Nature.- I. Introduction.- II. Stable Ouinone Methides in Nature.- III. Quinone Methides as Intermediates in Biochemical Processes.- References.- The Pyrrolizidine Alkaloids. II.- I. Introduction: Occurrence and Nature of the Pyrrolizidine Alkaloids.- II. The Free Bases and the Basic Hydrolysis Products.- III. The Acids Associated with the Pyrrolizidine Alkaloids.- IV. The Structure of the Native Alkaloids.- V. Biosynthesis.- VI. Pharmacology.- VII. Tables.- References.- Some Aspects ofVirus Chemistry.- I. Introduction.- II. The Chemistry of Viral RNA.- III. The Chemistry of Viral Protein.- References.- Namenverzeichnis. Index of Names. Index des Auteurs.- Sachverzeichnis. Index of Subjects. Index des Matieres.