Extracellular Vesicles as Matrix Messengers

The cells in our body release a wide variety of factors into the extracellular space that help to signal, regulate and build the extracellular matrix. One of the most fascinating of these factors are extracellular vesicles (EVs). These lipid membrane-covered particles have now emerged as a new powerful method of near and distant intercellular communication. EVs facilitate communication between cells and their extracellular environment, which includes solid tissues and body fluids.

This volume summarizes current knowledge on EVs as integral and active components of the extracellular matrix. It covers topics such as the interplay between EVs and ECM molecules and how cancer cells modify their microenvironment by releasing EVs. Additionally, it discusses how EVs can mediate tissue repair and regeneration by modulating matrix degradation, protein cross-linking, and matrix calcification. The book explores instances where EVs play a crucial role in conditions related to matrix biology, such as cancer and arthritis, and considers their potential as therapeutic agents for these medical conditions.

Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and extracellular vesicles will find this book is an excellent introduction into the field of EV biology with applications in matrix research.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Highlights the role of extracellular vesicles in matrix biology Describes how cancer cells modify their microenvironment via extracellular vesicles and ECM interactions Discusses how extracellular vesicles modulate matrix degradation and calcification for tissue repair

Auteur

Kirsi Rilla, PhD, is a group leader at the Institute of Biomedicine, University of Eastern Finland. She received her M.Sc. degree in cell biology from the University of Jyväskylä (1998). Her Ph.D. project in the Tammi research group was focused on intracellular trafficking of hyaluronan synthases and regulation of their activity (2006). The thesis work led to the discovery of hyaluronan-dependent filopodia that act as hyaluronan factories. Especially intriguing is her finding that those filopodia act as platforms for extracellular vesicle shedding. Dr Rilla is experienced on the cellular and molecular mechanisms of cancer, extracellular matrix, hyaluronan and the biology of extracellular vesicles. During her research career, she has specifically focused on modern in vitro imaging techniques. Her current project is focused on extracellular vesicles, mechanism contributing to regulation of their secretion, interaction and effects on target cells and utilization of EVs as specific carriers of therapy.

Contenu

Chapter 1. Manipulating the Matrix: Role of Extracellular Vesicles.- Chapter 2. Extracellular Matrix Remodeling in Physiological and Pathological Conditions: Insight into Extracellular Vesicles Contribution.- Chapter 3. Extracellular Matrix Modulation by Cancer-Derived Extracellular Vesicles: Impact on Cancer Malignancy.- Chapter 4. Role of Hyaluronan in Interactions of Tumor-Derived Extracellular Vesicles with Cells of Monocyte Origin.- Chapter 5. Extracellular Vesicles in Inflammation.- Chapter 6. Extracellular Vesicles in Synovial Fluid: Their role in Joint Homeostasis and Patophysiology.- Chapter 7. Extracellular Vesicles from Obese Adipose Tissue and Their Relationship with the Development of Comorbidities.- Chapter 8. Potential of Extracellular Vesicles as Therapeutics in Retinal Diseases.- Chapter 9. AFM-Based Mechanobiology of Extracellular Vesicles.- Chapter 10. Bioaffinity Recognition of Extracellular Vesicle Glycosylations.- Chapter 11. Imaging of EVs in the 3D Matrix Networks.