Extracellular Matrix Biomineralization of Dental Tissue Structures

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs).

The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed.

With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Auteur
Michel Goldberg is Professor Emeritus de catégorie exceptionnelle at the University of Paris V (University René Descartes). He has served on many committees for INSERM and for the International Association for Dental Research (IADR). Dr. Goldberg is a Past President of the IADR Mineralized Tissue Group and the Pulp Biology Group. He has been a member of the IADR Continental European Division since 1973 and has served on their board in numerous capacities, through to President and Past President. During his career, Dr. Goldberg has sat on scientific advisory boards for many international dental conferences. He was the Scientific President for the Annual Congress of the Association Dentaire Francaise (ADF) in 1992 and 2000 and presided over the annual ADF congress in 2003. He is a widely published author and co-author, with more than 270 scientific articles to his name as well as 13 books. He is a member of the editorial board of the Journal of Dental Research and a member of the board of advisory editors for numerous publications. Dr. Goldberg is a recipient of the Chevalier Ordre National du Mérite; he was also awarded the Distinguished Service Award from the IADR in 2003 and the IADR's Distinguished Scientist Award for Pulp Biology Research in 2006.

Pamela Den Besten is Professor in the Department of Orofacial Sciences, School of Dentistry, University of California San Francisco. She directs the Center for Children's Oral Health Research, and co-directs the DDS-PhD and PhD programs in Oral and Craniofacial Sciences within the School of Dentistry and the Graduate Division. Dr. Den Besten is President of the International Association for Dental Research (IADR) (2019-2020), and past Chair (2018-2019) of the Section on Dentistry & Oral Health Sciences, American Association for the Advancement of Science (AAAS). In 2009 she received the IADR Distinguished Scientist Award, Pulp Biology and Regeneration. She is a AAAS honorary Fellow. Dr. Den Besten has published over 125 scientific manuscripts in peer-reviewed journals, along with 18 book chapters. She has served on a number of editorial boards including the Journal of Dental Research, and Evidence Based Dentistry Journal, and reviews manuscripts for journals in her area of research expertise. Her research interests are focused on tooth formation, and in particular enamel and dentin regeneration and biomineralization. She is an international leader in enamel fluorosis research, and is interested in how fluoride can directly affect cell function.

Contenu
Part 1: Extracellular matrix molecules of mineralized structures.- Chapter 1: Collagen-derived mineralized structures (dentin, cementum, bone and cartilage) and non-collagenous ECM of enamel.- Chapter 2: ECM- nomenclature and functions.- Part 2: Collagen-derived extracellular matrix components: dentin, bone and cementum.- Chapter 3: Collagenous mineralized tissues: composition, structure, biomineralization.- Chapter 4: Non-collagenous ECM matrix components. Growth factors & cytokines involved in matrix mineralization.- Chapter 5: Odontoblast processes: new insights into its role in dentin mineralization.- Chapter 6: Small leucine rich proteoglycans (SLRPs) and Biomineralization.- Chapter 7: Cementum proteins beyond cementum.- Chapter 8: Biochemistry of non-collagenous proteins of bone.- Part 3: Enamel.- Chapter 9: Human tooth enamel, a sophisticated material.- Chapter 10: Proteinases in enamel development.- Chapter 11: Enamel matrix biomineralization- the role of pH cycling.- Chapter 12: Environmental factors and enamel/dentin defects.