Enzyme Catalysis in Organic Synthesis

This comprehensive three-volume set remains the standard reference in the field. It retains the application-oriented concept of past editions, while focusing on new developments. All the techniques are directly transferable from the lab to the industrial scale.

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.
Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.
All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.
A must for all chemists and biotechnologists.

Auteur
Karlheiz Drauz is Vice President International Scientific Relations of Evonik. He evaluates interesting topics in research and development and networks globally with academic and industrial institutions. He did his Ph.D. at the Technical University Stuttgart, Germany, and started his career at Degussa 1980 in various positions in research and development. Amoungst his research interests are amino acids, peptides, biological active compounds, asymmetric synthesis, metal and biocatalysis as well as process chemistry. He holds about 160 patents, about 100 scientific publications. Since 1992 he is honorary professor for organic chemistry at the University Würzburg, Germany.

Harald Gröger is since 2006 Professor for organic chemistry at the University of Erlangen-Nürnberg, Germany. He studied chemistry at the Universities of Erlangen-Nürnberg and Oldenburg, before he did his postdoc with Masakatsu Shibasaki at the University of Tokyo. He worked from 1998 to 2006 in industry, e.g. as senior project manager for White Biotechnology of Degussa. He received several awards, like the Degussa innovation prize for new products (2003) and for new and optimized processes (2005), the Thieme award in 2007 and the German business sectors innovation prize (2004). His research interests are enzyme catalyzed organic synthesis, design and use of biomimetic chemocatalysts as well as sustainable chemistry.

Oliver May is Competence Manager Biocatalysis and responsible for coordinating biocatalysis related activities of DSM Pharmaceutical Products. Before joining DSM in April 2006, he was with Degussa (now Evonik) in various functions; latest as General Manager of Degussa's Service Center Biocatalysis. He was educated in Germany, receiving a PhD degree in Technical Biology from the University of Stuttgart where he worked at the Institute of Biochemical Engineering for Prof. C. Syldatk and at the German Center for Biotechnology in Braunschweig with Prof. D. Schomburg. He joined Caltech as a postdoc in 1998 where he worked until 2000 in the group of Prof. F.H. Arnold on directed evolution of enzymes. Oliver May has authored more than 30 scientific contributions in Journals and Books and more than 15 patent applications. He his team was awarded several innovation awards on hydantoinase technology, whole-cell processes and the latest on recombinant pig liver esterase in its application for production of a pharma intermediate.

Texte du rabat
Reviews for previous editions of Enzyme Catalysis in Organic Synthesis include: "an unrivalled wealth of knowledge and experience... destined to become known as "The Handbook" for biological catalysis in organic chemistry", and "this book sets the standard in the field." This completely new edition is considerably extended, and fully updated and presents the insight of numerous world-leading practitioners. The use of enzymes in organic synthesis in both academia and industry has changed from being a seldom-used technique to common practice. The power of the technology results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology in organic synthesis. This book explains how and why enzymatic catalysis has developed into the crucial synthetic tool for the chemist that it is. A major driver in research and development in the chemical industry is to employ environmentally friendly processes, often named "green" or "sustainable". Synthetic biology is also facilitated by enzyme catalysis which offers fascinating opportunities in this respect and is, and will continue to be, one of the most important tools available to scientists aiming to maintain product and process development while protecting the environment and its resources. The new edition of this renowned handbook retains the classification of biocatalytic transformations by reaction type, and this comprehensive three-volume set guides the user through the latest innovations, provides analysis of important new trends, and will be an indispensable companion for all practitioners of chemical synthesis. Herbert Waldmann, a pioneer in the field, comments in his foreword of this third edition: "It is not only an invaluable source of knowledge and references, it also embodies a treasure that consists of a multitude of findings not yet exploited by the scientific community." A must-have for all scientists working in (bio)catalysis and modern organic chemistry.

Contenu
VOLUME 1

PART I PRINCIPLES OF ENZYME CATALYSIS

Introduction - Principles and Historical Landmarks of Enzyme Catalysis in Organic Synthesis
Concepts in Biocatalysis
Discovery of Enzymes
Rational Design of Enzymes
Directed Evolution of Enzymes
Production and Isolation of Enzymes
Reaction and Process Engineering

PART II HYDROLYSIS AND FORMATION OF C-O BONDS

Hydrolysis and Formation of Carboxylic Acid Esters
Hydrolysis and Formation of Epoxides
Hydrolysis and Formation of Glycosidic Bonds
Addition of Water to C¼C Bonds and its Elimination
Industrial Application and Processes Forming C-O Bonds

VOLUME 2

PART III HYDROLYSIS AND FORMATION OF C-N BONDS

Hydrolysis of Nitriles to Amides
Hydrolysis of Nitriles to Carboxylic Acids
Hydrolysis of Amides
Hydrolysis and Formation of Hydantoins
Hydrolysis and Synthesis of Peptides
C-N Lyases Catalyzing Addition of Ammonia, Amines, and Amides to C¼C and C¼O Bonds
Application of Transaminases
Industrial Applications and Processes Using Enzymes Acting on C-N Bonds

PART IV FORMATION AND CLEAVAGE OF C-C BONDS

Aldol Reactions
Acyloin and Benzoin Condensations
Cleavage and Formation of Cyanohydrins
Industrial Application and Processes Using Carbon-Carbon Lyases

PART V HYDROLYSIS AND FORMATION OF P-O BONDS

Hydrolysis and formation of P-O Bonds

PART VI REDUCTIONS

Reduction of Ketones and Aldehydes to Alcohols
Reduction of C¼C Double Bonds
Reductive Amination of Keto Acids
Industrial Application of Oxidoreductase catalyzed Reduction of Ketones and Aldehydes

VOLUME 3
PART VII OXIDATIONS

Oxyfunctionalization of C-H Bonds
Oxyfunctionalization of C-C Multiple Bonds
Oxidation of Alcohols, Aldehydes, and Acids
Baeyer-Villiger Oxidations
Aromatic Oxidations
Oxidation of C-N Bonds
Oxidation at Sulfur and Oxidation of Amino Groups
Halogenation
Industrial Application and Processes Using Biocatalysts for Oxidation Reactions

PART VIII ISOMERIZATIONS

Isomerizations
Industrial Application and Processes Using Isomerases

PART IX EXTENDED APPLICATIONS OF ENZYME CATALYSIS

Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed Reactions
Catalytic Antibodies
Chemoenzymatic Dynamic Kinetic Resolution and Related Dynamic Asymmetric Transformations
Biocatalysis in Materia…