Dopaminergic System Function and Dysfunction: Experimental Approaches

This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Contenu
Ultrastructural Study of Dopaminergic Axon Terminals.- Quantifying Dopaminergic Innervation in Rodents Using Unbiased Stereology.- Dendrites Crossing Borders: Quantifying The Distribution of Individual Dopaminergic Neurons' Dendritic Tree in Pars Compacta and Pars Reticulata.- Characterizing Dopamine Transporter Mediated Uptake and Efflux in Brain Slices: A New Approach.- Modeling Pacemaking, Bursting and Depolarization Block in Midbrain Dopamine Neurons.- Electrophysiological Characterization of Dopaminergic Neurons of the Rat Substantia Nigra Compacta.- Pulmonary Inhalation to Assess Effects of Coca-Paste On Behavior and Dopamine Neurotransmission.- Ethanol Intake On Preclinical Models: Methods of Assessment and Effects On Dopamine Signaling.- Preclinical models of THC and Nicotine Exposure During Adolescent Brain Development: Modelling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission.- The MAM Model to Study the Role of Dopamine in Schizophrenia.- Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior.- Multi-circuit Recording in Animal Models of Parkinson.- Neuroimaging Human Dopamine-Related Neurophysiology across Development.- Dopaminergic Control of Actions and Habits.