Single Molecule Science

Auteur

Dmitrii E. Makarov is a professor of chemistry at the University of Texas at Austin. He earned a PhD in theoretical physics from the Institute of Chemical Physics in Moscow. His expertise is in theoretical and computational chemical physics and in biophysics.

Texte du rabat

The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science, and the utility of single-molecule methods has proven invaluable in such fields as nanoscience and molecular biology. This book provides a general framework necessary for understanding single-molecule phenomena. It introduces the relevant mathematical and physical concepts, and then discusses various approaches to the problem of interpreting single-molecule data. It thoroughly explains the physical principles underlying the major classes of single-molecule experiments, such as fluorescence measurements, force-probe spectroscopy, and nanopore experiments.

Contenu

A Brief History of Thought and Real Single-Molecule Experiments. How the Properties of Individual Molecules Are Measured. The Kinetics of Chemical Reactions: Single-Molecule Versus "Bulk" View. How Molecules Explore their Energy Landscapes. Microscopic View of the Rate of a Chemical Reaction: A Single-Molecule Perspective. Molecular Transition Paths: Why Going Uphill May Be Faster. Properties of Light Emitted by a Single Molecule and What It Can Tell Us About Molecular Motion. Single-Molecule Mechanics. Nonequilibrium Thermodynamics of Single Molecules: The Jarzynski and Crooks Identities. Single-Molecule Phenomena in Living Systems. Appendix A Probability Theory, Random Numbers and Random Walks. Appendix B Appendix B: Elements of Statistical Mechanics.