Denitrogenative Transformation of Nitrogen Heterocycles

First of its kind book on Denitrogenative Transformations helps researchers and scientists working in organic chemistry, organometallic chemistry, and transition metal catalysis, as well as academicians, industry professionals. It comprises of all the types of polynitrogen heterocycles that are studied to undergo denitrogenative transformation. The first chapter introduces denitrogenative Transformation, its historical aspects and present status. The following chapters use a reaction-based approach to explain denitrogenative transformations in detail.

Auteur

Pazhamalai Anbarasan obtained his Ph.D. from the Indian Institute of Science (IISc), Bangalore, after which he moved to Germany as an Alexander-von-Humboldt foundation post-doctoral fellow at the Leibniz Institute for Catalysis (LIKAT). He spent another year at the University of California, Berkely, he returned to India in December 2011 to start his academic career at the Department of Chemistry, Indian Institute of Technology Madras (IIT Madras), where currently he is a professor. His research program is focused on the development of new synthetic strategies employing transition-metal catalysis with special focus on asymmetric synthesis and their implementation in organic synthesis.

Texte du rabat

Comprehensive resource exploring a unique chemical transformation that generates new compounds with diverse properties for modern organic synthesis research Denitrogenative Transformation of Nitrogen Heterocycles explores all 10 polynitrogen heterocycles that are known to undergo denitrogenative transformations to date. Following highlights on the remarkable modifications encountered in the synthesis of nitrogen heterocycles, the chapters use a reaction-based approach to explain denitrogenative transformations in detail. This book covers the exponential growth in scientific literature in the last few decades for denitrogenative reactions of polynitrogen heterocycles which play a key role in natural products, medicinal chemistry, pharmaceuticals, biochemistry, and material sciences. This book also discusses denitrogenative cascade reactions, which accomplish powerful transformations from simple polynitrogen heterocycles to more complex molecules in modern synthetic chemistry. Written by a highly qualified academic with significant experience in the field, Denitrogenative Transformation of Nitrogen Heterocycles covers sample topics including:

• Transannulation of N-sulfonyl-1,2,3-triazoles with polar multiple bonds such as carbonyls and nitriles and non-polar multiple bonds such as alkenes, alkynes, and allenes
• Insertion of azavinyl carbenes to C-X/X-X bond, denitrogenative rearrangements of N-sulfonyl-1,2,3-triazoles, and denitrogenative transformations of NH- and N-fluoroalkyl-1,2,3-triazoles
• Metal-catalyzed and metal-free denitrogenative transformations of pyridotriazoles and denitrogenative transannulation of benzotriazoles and thiadiazoles
• Denitrogenative transformations of tetrazoles and radical denitrogenative transformations of polynitrogen heterocyclesThe first book of its kind on the subject, Denitrogenative Transformation of Nitrogen Heterocycles is an essential reference for researchers and scientists working in organic chemistry, organometallic chemistry, and transition metal catalysis, as well as academics and industry professionals in related fields.

Contenu
Table of Content

1. Synthesis of N-sulfonyl-1,2,3-triazoles and related compounds
2. Transannulation of N-sulfonyl-1,2,3-triazoles with polar multiple bonds such as carbonyls and nitriles
3. Transannulation of N-sulfonyl-1,2,3-triazoles with non-polar multiple bonds such as alkenes, alkynes and allenes
4. Transannulations of N-sulfonyl-1,2,3-triazoles with Carbo/Heterocycles
5. Insertion of azavinyl carbenes to C-H/X-H bond
6. Insertion of azavinyl carbenes to C-X/X-X bond
7. Denitrogenative rearrangements of N-sulfonyl-1,2,3-triazoles
8. Denitrogenative transformations of NH- and N-fluoroalkyl-1,2,3-triazoles
9. Asymmetric perspective on denitrogenative transformation of 1,2,3-triazoles
10. Denitrogenative transformations of triazoloindoles
11. Metal-catalyzed denitrogenative transformations of pyridotriazoles
12. Metal-free denitrogenative transformations of pyridotriazoles
13. Denitrogenative transannulation of benzotriazoles
14. Denitrogenative transannulation of thiadiazoles
15. Denitrogenative transformations of benzotriazinones and related compounds
16. Denitrogenative transformations of 3-aminoindazoles
17. Denitrogenative transformations of tetrazoles and pyridotetrazoles
18. Radical denitrogenative transformations of polynitrogen heterocycles
19. Application of denitrogenative transformations in synthesis of natural products