Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

Nominated as an outstanding Ph.D. thesis by the University of Cambridge, Cambridge, UK Presents a comprehensive analysis of the common barriers and unique challenges associated with the clinical translation of optical imaging techniques Includes a roadmap to clinical translation, which the reader may apply to guide rapid development and streamlined clinical implementation of their own novel techniques Demonstrates the development of two novel endoscopic imaging technqiues, from inception to deployment in first-in-human clinical pilot studies, describing the strategies used to achieve rapid translation

Auteur

Dale J. Waterhouse received first class B.A. and M.Sci. degrees in Natural Sciences from the University of Cambridge in 2014. He recieved a Ph.D.degree in Physics from the University of Cambridge in 2018, where his thesis work focused on development of novel endoscopic imaging techniques. This culminated in the development of two clinically translatable multispectral endoscopes, one for early detection of cancer in the oesophagus, and the other for delineation of cancer in surgical resection of pituitary adenoma. In 2018 he was awarded an EPSRC Doctoral Fellowship, allowing him to continue this work, deploying these devices in first in human clinical trials.

Contenu
Translation of Optical Imaging Techniques.- Flexible Endoscopy: Early Detection of Dysplasia in Barrett's Oesophagus.- Flexible Endoscopy : Device Architecture.- Flexible Endoscopy: Optical Molecular Imaging.- Flexible Endoscopy: Multispectral Imaging.- Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma.- Conclusions and Outlook.- Appendix. <p