Molecular Basis for Microcirculatory Disorders

A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.

Contenu

1. Molecular Mechanisms of Leukocyte Adhesion.- 2. Leukocyte Adhesion Mechanisms in Chronic Inflammatory Disease.- 3. Endothelial-Dependent Mechanisms of Monocyte Recruitment.- 4. Adhesion and Communication Between Lymphocytes and Endothelial Cells.- 5. Steady and Unsteady Fluid Shear Control of Atherosclerosis.- 6. Fluid Shear Response in Leukocytes.- 7. Fluid Shear Stress Control of Vascular Smooth Muscle.- 8. Molecular Mechanisms of Juxtacrine Cell Signalling in Microvascular Responses and Inflammation.- 9. Microvascular Effects of the Heme Oxygenase-CO System.- 10. Reactive Oxygen and Nitrogen Species:Activating Signals in Inflammation.- 11. Mechanisms for Microvascular Cell Activation: Pancreatic Digestive Enzyme Derived Inflammatory Mediators in Shock.- 12. Regulation of Neutrophil Apoptosis.- 13. Endothelial Cell Apoptosis Under Fluid Flow.- 14. Mechanisms of Parenchymal Apoptosis.- 15. Molecular Determinants of Reperfusion-Induced Leukocyte Adhesion.- 16. Risk Factors for Cardiovascular Disease Amplify Reperfusion-Induced Inflammation and Microvascular Dysfunction.- 17. Early and Late Preconditioning Prevent Ischemia/Reperfusion Injury:Signalling Pathways Mediating the Adaptive Metamorphosis to a Protective Phenotype in Preconditioned Tissues.- 18. Oxygen Radicals and Pathogenesis of Stroke.- 19. Roles of Polymorphonuclear Leukocytes in Focal Cerebral Ischemia.- 20. Role of Endothelium in Cerebral Ischemia.- 21. Leukocyte-Endothelial Interactions Following Myocardial Ischemia.- 22. Ischemic Preconditioning and Apoptosis in Myocardial Ischemia.- 23. Gene Transfer Strategies and Therapeutic Applications for Cardiovascular Ischemic Diseases.- 24. Inflammation in Venous Disease.- 25. Microvascular Mechanisms Controlling CVI.- 26. Microvascular Adhesion Mechanisms inChronicVenous Insufficiency:a Pharmacological Approach.- 27. Microvascular Pathobiology in Diabetes.- 28. Microvascular Permeability in Diabetes.- 29. Involvement of Leukocytes in Diabetic Retinopathy and Choroidopathy.- 30. Diabetic Microangiopathy.- 31. Hypertension and Microcirculation.- 32. Microcirculation in Hypertension.- 33. Pharmacological Improvement of the Microcirculation.