Cryptic Enzymes and Moonlighting

Auteur
Helen Irving is a Professor in Biomedical Sciences and is a member of the La Trobe Institute for Molecular Sciences (LIMS) in Melbourne, Australia. Helen's current research centers on understanding inflammatory signals at the molecular level to develop new and improved approaches to managing inflammatory conditions. Helen obtained her PhD in Biochemistry from The University of Melbourne and conducted post-doctoral work at Vanderbilt University (USA) and The University of Kentucky (USA) before returning to Australia to take up an ARC Post-Doctoral Fellowship at La Trobe University. For most of her career, she has been a teaching and research academic based at the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. Helen moved to the La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University in 2017. Dr. Chris Gehring is based at the Università degli Studi di Perugia UNIPG, in the Department of Chemistry, Biology & Biotechnology. His research focuses on plant signalling peptides, with a focus on various peptide signalling molecules in development, defense, and homeostasis. He has published widely in such peer reviewed journals as Nature, Molecular Plant, Trends in Genetics, and the *Journal of Biological Chemistry.*Dr. Aloysius Wong earned a PhD in Bioscience from King Abdullah University of Science and Technology (KAUST), Saudi Arabia, as well as a MA in Biotechnology from the University of Cambridge, UK. In past positions, he has served as a post-doctoral researcher at the French National Centre for Scientific Research. Dr. Wong seeks to understand, from a molecular perspective, how plants, despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and launch short- and long-term biological responses that enable them to survive in environments considered hostile to plants. Dr. Wong has published widely in peer reviewed journals.

Texte du rabat
Cryptic Enzymes and Moonlighting, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.

The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.

Contenu

1. Introduction and overview of moonlighting enzymes in signal cascades
   Constance Jeffery
   
   2. Extracellular vesicles enabling moonlighting proteins
      Pamali Fonseka, Sriram Gummadi, Akbar Lulu Marzan, Sai Vara Prasad Chitti, Suresh Mathivanan
   3. Eukaryotic moonlighting proteins that assist microbial infections
      Mohd Akif
   4. Moonlighting proteins in neurobiology signaling mediated by G protein coupled receptors (GPCRs).
      Adrián Martínez Cortés, Mariana Mirchandani-Duque, Aracelis Hernández-García, Dasiel Oscar Borroto Escuela, Adam Danielson, Esther Berrocoso, Malak Choucri, Jose Laffita, Kjell Fuxe
   5. Metabolic enzymes co-opted in oncogenic signaling
      Bailey Nance, Brian Keith, Marie Simon
   6. Metabolic enzymes moonlighting as RNA binding and regulatory proteins
      Constance Jeffery
   7. Cryptic enzymes as fine tuners of signaling cascades
      Aloysius Wong, Helen Irving, Christoph Gehring
   8. Dual function plant cryptic nucleotide cyclases
      Marcella Bracale, Maria Concetta de Pinto, Cecilia Lasorella, Eleonora David, Stefania Fortunato, Candida Vannini, Guido Domingo
   9. Crypto adenylate cyclases coming of age
      Adriana Szmidt-Jaworska, Brygida wie awska
   10. Crypto adenylate cyclases moonlighting with phosphodiesterases in complex proteins
       Mateusz Kwiatkowski, Krzysztof Jaworski
   11. Gas sensing H-NOX hemo proteins in plants and beyond
       Chuyun Bi, Christoph Gehring, Aloysius Wong
   12. Modulating the immune response via cryptic enzymes
       Trang Nguyen, Helen Irving, Cassandra Cianciarulo, Joseph Tucci, Ilona Turek
   13. Cryptic moonlighting enzymes enable crosstalk with other signaling molecules
       Julia Davies
   14. Identifying hidden moonlighting proteins and protein regions
       Daisuke Kihara
   15. Computational approaches and bioinformatic tools for the identification of cryptic enzymes
       Shiyu Jiang, Aloysius Wong, Chuyun Bi
   16. Establishing cryptic enzyme interactomes
       Ilona Turek, Santosh Ramabhadra Rao Tata, Helen Irving
   17. Assessing contributions of moonlighting proteins to signal cascades
       Jiri Friml, Linlin Qi
   18. Uncovering moonlighting proteins in cell organelles
       Anushka Date, Helen Irving, Santosh Ramabhadra Rao Tata