Concepts in Vaccine Development

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Ziel des Buches ist es, dem Leser einen Überblick über die aktuellen Strategien zur Impfstoffenwicklung zu vermitteln. Bei der Bekämpfung vieler ansteckender Krankheiten haben sich Impfungen als überaus wirksam erwiesen. Noch immer aber führen zahlreiche ansteckende Krankheiten zu großen Problemen im Gesundheitsbereich, die nicht durch gegenwärtig zur Verfügung stehende Impfstrategien gelöst werden können.
Jüngste Erfolge in der Grundlagenforschung und im Bereich der Biotechnologie haben jedoch den Weg für die Entwicklung einer neuen Generation von Impfstoffen geebnet. Dieses Buch legt seinen Schwerpunkt auf die Beschreibung dieser neuen Konzepte und Strategien in der Impfstoffentwicklung. Es vermittelt einen umfassenden Überblick aller dabei zu berücksichtigenden Aspekte von der Forschung im Labor bis hin zum Impfstoffeinsatz.

Auteur
Stefan H.E. Kaufmann is the Director of the Department of Immunology at the Max Planck Institute for Infection Biology in Berlin, Germany. Having obtained his academic degrees from the Johannes Gutenberg University in Mainz he spent his time as post-doc at the Max Planck Institute for Immunobiology and later became full Professor for Microbiology and Immunology at the University of Ulm. Professor Kaufmann has authored over 600 scientific publications and has received numerous scientific awards including the Aronson Prize of the State of Berlin, the Smith Kline Beecham Science Prize for Medical Research, the Merckle Research Prize, The Robert Pfleger Prize, The Pettenkofer Prize, The Research Prize of the German Society for Hygiene and Microbiology and the Alfred Krupp Prize for Young Professors. He is also member of the Berlin-Brandenburg Academy of Sciences and the Leopoldina Academy of Natural Sciences and a long-time Editor-in-Chief of the Journal Microbes and Infection.

Texte du rabat

Frontmatter -- Preface -- Bicentennial of the first vaccination by Edward Jenner / Kaufmann, Stefan H.E. -- Contents -- 1. The Need for New Vaccines -- 1.1. Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy / Ewald, Paul W. -- 1.2. Economic Perspectives on Vaccine Needs / Ashley, Robert V. / Murray, Christopher J. L. -- 1.3. Future Immunization Strategies - Considerations from the Public Health View / Dittmann, Sieghart -- 1.4. The New Pertussis Vaccines / Klein, David L. / Heilman, Carole -- 2. General Principles of Immunology -- 2.1. Basic Principles of Immunity Against Intracellular Bacteria and Protozoa / Szalay, Gudrun / Kaufmann, Stefan H. E. -- 2.2. Viral Immunity and Vaccine Strategies / Woodland, David L. / Cole, Geoffrey A. / Doherty, Peter C. -- 2.3. Broadly Reactive HLA Restricted Cell Epitopes and Their Implications for Vaccine Design / Sidney, John / Kubo, Ralph T. / Wentworth, Peggy A. / Alexander, Jeff / Chesnut, Robert W. / Grey, Howard M. / Sette, Alessandro -- 2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack / Bretscher, Peter -- 2.5. The Impact of the Type 1 and Type 2 Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites / Bogdan, Christian / Röllinghoff, Martin -- 3. General Principles of Vaccinology -- 3.1. Modern Adjuvants. Functional Aspects / Morein, Bror / Lövgren-Bengtsson, Karin / Cox, John -- 3.2. Biodegradable Microspheres as Vehicles for Antigens / Kersten, Gideon F.A. / Gander, Bruno -- 3.3. Peptide Based Vaccines / Schild, Hansjörg / Rammensee, Hans-Georg -- 3.4. Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens / Hormaeche, Carlos E. / Khan, C. M. Anjam -- 3.5. Genetic Detoxification of Bacterial Toxins / Rappuoli, Rino / Pizza, Mariagrazia -- 3.6. Recombinant Virus as Vaccination Carrier of Heterologous Antigens / Perkus, Marion E. / Paoletti, Enzo -- 3.7. Naked DNA Vaccination / Shiver, John W. / Ulmer, Jeffrey B. / Donnelly, John J. / Liu, Margaret A. -- 3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin / Holmgren, Jan / Czerkinsky, Cecil / Sun, Jia-Bin / Svennerholm, Ann-Mari -- 4. Specific Vaccination Strategies -- 4.1. Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design / Ghiara, Paolo / Covacci, Antonello / Telford, John L. / Rappuoli, Rino -- 4.2. Malaria Vaccination / Patarroyo, Manuel E. / Amador, Roberto -- 4.3. Vaccination Against Schistosomiasis: Concepts and Strategies / Riveau, Gilles J. / Capron, André -- 4.4. AIDS Vaccination / Norley, Stephen / Kurth, Reinhard -- 4.5. Vaccination Therapy Against Autoimmune Diseases / Cohen, Irun R. / Mor, Felix -- Contributors -- Index