Cardiovascular Disease

The Fourteenth Washington International Spring Symposium, held in Washington, D.C., in June 1994, brought together over 400 leading scientists from 21 countries to review and update research on cardiovascular disease. This group satisfied the symposium goals of formulating a more comprehensive and integrated picture of the events contributing to atherosclerosis and of exploring modified gene expression as an to understanding the causes of atherosclerosis and providing clues to the approach prevention and treatment. This volume contains most of the papers presented at the eight plenary sessions together with selected contributions from the special sessions. The multidisciplinary nature of the chapters and their authors should stimulate the interests of biochemists, cell and molecular biologists, pathologists, pharmacologists, epidemiologists, nutritionists, and clinicians. The volume is divided into eight sections which reflect the focus of the plenary sessions. Part I focuses on the pathophysiology of atherosclerotic plaques and predicts that the nature of the fibrous cap of atheroma determines plaque disruption and clinical events. Papers in Part II deal with atherogenic lipoproteins. The introductory paper reviews the current view of the role of plasma lipoproteins in atherosclerosis. With respect to the newer members on the list,: [oxidized LDL, Lp(a)] evidence is provided that suggests the involvement of one major gene in the development of oxidized LDL lipids. the expression of inflammatory genes, and the development of aortic fatty streaks.

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Proceedings of the Fourteenth Washington International Spring Symposium at the George Washington University held in Washington, D.C., June 6-10, 1994.

Contenu
I - Atherogenesis.- 1. Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease - An Overview.- 2. Expression of 92 kDa Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture.- 3. Proteinases and Restenosis: Matrix Metalloproteinases and Their Inhibitor and Activator.- II - Atherogenic Lipoproteins.- 4. Current Concepts of the Plasma Lipoproteins and their Role in Atherosclerosis - An Overview.- 5. Homeostasis of Lipid Oxidation in the Artery Wall.- 6. Molecular Basis for the Lysine Binding Polymorphism of Lipoprotein (a).- 7. Triglyceride-rich Lipoprotein Metabolism and Diabetes.- 8. Apolipoprotein E: Paradoxes Abound.- 9. The Role of Second Messenger Pathways in the Pathophysiology of Hyperapo-B and Premature Coronary Artery Disease.- III - Anti-Atherogenesis/Cholesterol Removal Mechanisms.- 10. The Role of HDL Receptors in Removal of Cellular Cholesterol.- 11. The Defect in HDL3 Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts.- 12. Cholesterol Efflux from Cells in Culture, Reconstituted Particles, and Whole Serum.- 13. Apo A-1 Containing Particles and Atherosclerosis.- IV - Signal Transduction in Vascular Proliferation.- 14. Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease - An Overview.- 15. Identification of FGF-1-Inducible Genes by Differential Display.- 16. Antioxidants and Endothelial Expression of VCAM-1: A Molecular Paradigm for Atherosclerosis.- 17. Mechanisms of Potentiation of PDGF in Atherosclerosis.- 18. The Regulation of Normal and Pathological Angiogenesis by Vascular Endothelial Factor Napoleone Ferrara.- 19. Characterization of Developmentally Associated Changesin Rabbit Vascular Smooth Muscle Cells.- V - Adhesion Pathobiology.- 20. Molecular Basis and Pathologic Consequences of Neutrophil Adherence to Endothelium.- 21. The Distribution of Adhesion Molecules in Normal and Atherosclerotic Arteries and Aortas.- 22. L-Selectin Regulation of Lymphocyte Homing and Leukocyte Rolling and Migration.- 23. L-Selectin, A Lectin-Like Receptor Involved in Normal Lymphocyte Recirculation and Inflammatory Leukocyte Trafficking.- 24. New Perspectives in P-Selectin Biology.- 25. Rat P-Selectin Mediates Neutrophil-Platelet Interactions via Two Sites (2360, 7690) Located on Its Lectin Domain.- VI - Thrombosis/Fibrinolysis.- 26. Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor (PAI-1).- 27. Local Increase in PAI-2 on Stimulation of Monocytes with Modified LDL.- 28. Structure, Function, and Regulation of the Urokinase Receptor.- 29. Role of the LDL Receptor-Related Protein in Proteinase and Lipoprotein Catabolism.- 30. Molecular Biology of Tissue Factor.- 31. Thrombin Receptor: Structure and Function.- 32. Antiplatelet Effects of Direct Acting Thrombin Inhibitors and Platelet GPIIb/IIIa Antagonists: Comparative Analysis.- 33. Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties.- 34. The Hemostatic Response to Arterial Injury invivo: Behavior of Prothrombin at the De-endotheliased Aorta Wall.- 35. Plasma Coagulation Factors in Emergency Room Patients with Acute Chest Pain and Subsequent Hospitalization: Myocardial Infarction, Coronary Artery Disease, and Hypertension.- VII - Modified Gene Expression/Clues to Cause, Prevention, and Treatment of Atherosclerosis.- 36. Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again.- 37. Genetic Manipulation of LipoproteinReceptors: Implications for Lipid Metabolism and Atherosclerosis.- 38. Genetic Models of Vascular Disease.- 39. Generation and Characterization of Apolipoprotein C1-Deficient Mice.- 40. Studies of Apolipoprotein B and Lipoprotein(a) in Transgenic Mice.- 41. Isolation of Novel Genes Regulated by Dietary Cholesterol by a PCR-Based Subtraction Library.- VIII - Atherosclerosis Prevention and Public Policy.- 42. Cholesterol and Mortality: What Can Meta-Analysis Tell Us?.- 43. Screening for High Blood Cholesterol: A Risky Enterprise.- 44. Cholesterol Lowering, Low Cholesterol, and Mortality.- 45. Bavarian Cholesterol Screening Project (BCSP).