Bronchiolitis Obliterans Syndrome in Lung Transplantation

This book offers a concise review of current understanding of delayed lung allograft dysfunction and the pathogenesis of obstructive bronchiolitis. Each chapter presents key points and summaries updating issues concerning the diagnosis and management of BOS.

Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the diagnosis and management of BOS. In-depth chapters provide readers with a comprehensive understanding of the definition and changing perceptions of the nature of BOS as a clinical and pathologic entity, immune and non-immune mechanisms that have been identified as risk factors for the development of BOS, and interventions that may prove to be clinically useful for the prevention or treatment of BOS. In addition to outlining the current state of knowledge, each chapter provides the reader with the most current and ongoing research in the field as well as identifies areas where future research is needed. Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important new text, that is essential reading for pulmonologists, primary care practitioners, respiratory care practitioners and clinical researchers.

Delivers a concise review of the current understanding of delayed lung allograft dysfunction and the pathogenesis of obliterative bronchiolitis Each chapter contains keywords and a summary The current state of knowledge is outlined in each chapter

Contenu

Bronchiolitis Obliterans Syndrome and Chronic Lung Allograft Dysfunction: Evolving Concepts and Nomenclature.- Airway Pathology in Lung Transplants.- Non-Bronchiolitis Obliterans Syndrome Forms of Chronic Lung Allograft Dysfunction.- The Role of Thoracic Imaging in the Diagnosis of BOS and Related Disorders.- Making a Confident Diagnosis of Obliterative Bronchiolitis.- The Role of Alloimmune T-Cell Responses in Obliterative Bronchiolitis.- Antibody-Mediated Rejection and the Bronchiolitis Obliterans Syndrome.- Innate Immune Responses and Bronchiolitis Obliterans Syndrome.- Mechanisms of Fibrogenesis in Post-Transplant Bronchiolitis Obliterans.- The Role of Autoimmunity in the Pathogenesis of Obliterative Bronchiolitis.- The Role of Infections in BOS.- Gastroesophageal Reflux and Aspiration in Chronic Lung Allograft Dysfunction and Bronchiolitis Obliterans Syndrome: Detection and Treatment.- Bronchiolitis Obliterans Syndrome in Children.- Immunosuppression for the Prevention and Treatment of BOS.- Macrolides for the Prevention and Treatment of BOS.- Other Treatments for Bronchiolitis Obliterans Syndrome.