Base-Metal Catalysis 1

Recent advances in catalytic methods based on earth-abundant metals are discussed.

Catalysis with earth-abundant metals, often referred to as base metals, is having a transformative impact on synthetic chemistry. Research in this area is driven not only by the common interest in the sustainability of chemical synthesis but also by the vast opportunity to discover and develop novel reaction chemistry that is not attainable with rare and precious metal catalysts. This work provides representative developments in base-metal catalysis, specifically catalysis with 3d-transition metals, in a format suitable for practitioners of organic synthesis.

Volume 1 is focused on recent advances in copper and nickel catalysis, including Ullmann-type coupling, reductive coupling and cross-coupling reactions, CH activation and functionalization, and alkene hydrofunctionalization and difunctionalization. Methods for the installation of important functional groups such as trifluoromethyl and carboxyl, and for the aerobic oxidation of alcohols are also covered.

Contenu

1 Introduction
1.1 Modern Ullmann-Type Couplings
1.2 Copper(I) Hydride Catalyzed Transformations
1.3 Copper-Catalyzed Alkene Difunctionalization
1.4 Copper-Catalyzed CH Functionalization via Radicals
1.5 Copper-Catalyzed Directed CH Functionalization
1.6 Copper-Catalyzed Acidic CH Functionalization
1.7 Copper-Catalyzed/Mediated Trifluoromethylation and other Fluoroalkylations
1.8 Copper-Catalyzed Aerobic Oxidation of Alcohols
1.9 Base-Metal-Catalyzed Carboxylation Using Carbon Dioxide
1.10 Nickel-Catalyzed Cross-Electrophile Coupling Reactions
1.11 Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions
1.12 Nickel-Catalyzed Alkene Dicarbofunctionalization
1.13 Nickel-Catalyzed Cross Coupling Involving Alkenes
1.14 Nickel-Catalyzed Directed CH Functionalization
1.15 Nickel-Catalyzed Nondirected CH Functionalization
1.16 Nickel-Catalyzed Bond Activation for Functional-Group Shuttling
1.17 Nickel-Catalyzed Cross Coupling via CO and CN Activation