Leukaemia Diagnosis

Auteur

Barbara J. Bain is an Australian haematologist. She is Professor of Diagnostic Haematology at the Imperial College London Faculty of Medicine and a consultant at St Mary's Hospital, London. She is known as the author of reference textbooks in the field of haematology that form the core curriculum for laboratory morphology and pathology. She recently received an AM in the 2020 Queen's Birthday Honours and in 2018 a European Haematology Association Mentoring and Teaching Award. Mike Leach is a haematologist with an interest in diagnostic haematopathology. He is a Consultant at the Beatson West of Scotland Cancer Centre and Gartnavel Laboratory in Glasgow, UK. He is known for a series of textbooks in this field with a focus on haematology diagnosis and the application of flow cytometry.

Texte du rabat

Authoritative reference on classifying and diagnosing leukaemia, with practical guidance on using various laboratory techniques included Leukaemia Diagnosis is a practical reference on the principles of leukaemia diagnosis and classification that illustrates and explains in a user-friendly way how different laboratory techniques are used to achieve an accurate interpretation. To aid in reader comprehension, over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma are included, supplemented by histological, cytogenetic and immunophenotyping images. This newly revised and updated Sixth Edition includes recent developments, highlights the growing importance of molecular genetics, and incorporates the recent 5th edition of the WHO guidelines and the International Consensus Classification for leukaemia diagnosis and classification throughout the text. Information on cytogenetic and molecular genetic abnormalities in leukaemia is also included, along with characteristic immunophenotypic characteristics of different categories of leukaemia. Written by world-renowned authors in the field, Barbara Bain and Mike Leach, Leukaemia Diagnosis covers sample topics such as:

• The nature of leukaemia, cytology, cytochemistry, and the morphological classification of acute leukaemia, with an index of commonly used abbreviations
• Immunophenotyping and cytogenetic/molecular genetic analysis, and integration of morphological, immunophenotypic and genetic information with the WHO classifications
• Acute lymphoblastic leukaemia, acute leukaemia of ambiguous lineage, and the myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
• Chronic myeloid leukaemias, lymphoid leukaemias of mature B, T, and natural killer cells, and leukaemia diagnosis in resource-poor countries The Sixth Edition of Leukaemia Diagnosis is a highly valuable resource for trainee haematologists and laboratory scientists in haematology and related disciplines. The text also serves as a useful reference and teaching aid for those who already have expertise in this field.

Contenu

Preface vii

Acknowledgements ix

Commonly Used Abbreviations xi

1 The Nature of Leukaemia, Cytology, Cytochemistry and the Morphological Classification of Acute Leukaemia 1

2 Immunophenotyping and Cytogenetic/Molecular Genetic Analyis 75

3 Acute Myeloid Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information: the WHO and International Consensus Classifications 141

4 Acute Lymphoblastic Leukaemia and Acute Leukaemia of Mixed or Ambiguous Lineage 271

5 The Myelodysplastic Syndromes, the Myelodysplastic/Myeloproliferative Neoplasms and Juvenile Myelomonocytic Leukaemia 327

6 Chronic Myeloid Leukaemias 411

7 Lymphoid Leukaemias of Mature B, T and Natural Killer Cells 469

8 Leukaemia Diagnosis in Resource- Poor Countries 593

Index 607