Antidiabetic Drug Discovery from Natural Products

Auteur
Dr Rupesh V. Chikhale earned his Ph.D. in Pharmaceutical Sciences from Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra (India) in 2015. He specializes in medicinal chemistry and computer-aided drug discovery. He works as a postdoc at the University of Manchester and the UCL School of Pharmacy, London, UK. Dr. Yogesh A. Kulkarni works as an Associate Professor and Associate Dean at Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai. He has 17 years of teaching and research experience. His research focuses on the pharmacology of natural products. He is studying the effects of various natural products on diabetes and its complications. He has published 105 papers in the journal of repute. Dr. Yogesh has authored 09 books, 26 book chapters and filed 02 patents. He has fetched over Rs.1.5 crore in research funding from various agencies. He is the recipient of the prestigious DST-INSPIRE Faculty Award” given by Govt. of India.

Dr Shailendra S. Gurav has a Doctorate in the Faculty of Medicine from RTM University Nagpur, India and is currently affiliated as a Professor at Goa College of Pharmacy, Goa, India. Dr Gurav is the recipient of the 'Senior Research Fellowship' of the 'Indian Council of Medical Research', New Delhi, India and was also awarded the 'International Travel Fellowship' by ICMR, CICS, and the Phytochemical Society of Europe and Asia. He serves as 'Advisor' for 'American Herbal Pharmacopeia', Associate Editor for the Journal of Ayurveda and Integrative Medicine (Elsevier), Guest Editor for Frontiers in Pharmacology, and Editorial Board member and Reviewer for several International journals. He has published more than 80 research papers in International and National peer-reviewed journals. Currently, 11 book chapters, 02 books, and 04 Indian patents are in his credit. His research interests are Ayurveda Biology, Natural Products Research, Computational Biology and Herbal Nanotechnology.

Dr. Nilambari S. Gurav has a Doctorate in Pharmaceutical Sciences from SGBA University Amaravati, India and currently affiliated as an Assistant Professor at PES's Rajaram and Tarabai Bandekar College of Pharmacy,Ponda, Goa University, India. Dr. Gurav is the recipient of the 'Junior Research Fellowship' of University Grants Commission, New Delhi, India. She has published more than 50 research papers in International and National peer-reviewed journals. Currently, 07 book chapters, 02 books, and 04 Indian patents are in her credit. Her research interests are Ayurveda Biology, Natural Products Research, Computational Biology and Herbal Nanotechnology.

Prof. Mrs. Uchenna Estella Odoh holds B. Sc degree in Pure and Industrial Chemistry, Master's Degree in Pharmaceutical and Medicinal Chemistry, Master's Degree in Pharmacognosy and Environmental Medicines and Ph.D in Pharmaceutical and Medicinal Chemistry all from the University of Nigeria, Nsukka. She is a Professor in the Department of Pharmacognosy and Environmental

Texte du rabat

Antidiabetic Drug Discovery from Natural Products provides up-to-date and in-depth information, practical understanding, and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, and graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds.

Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, the book describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing both current and prospective uses.

Contenu

Section 1: Putative antidiabetic drugs

1. Natural products in antidiabetic drug discovery: Historical perspective
2. Natural products in antidiabetic drug discovery: advances and opportunities

Section 2: Plant bioactives and their antidiabetic potential

3. Antidiabetic flavonoids from plant source
4. Antidiabetic terpenoids from plant source
5. Antidiabetic potential of plant alkaloids
6. Antidiabetic carbohydrates from natural sources
7. Antidiabetic potential of glycosides
8. Antidiabetic potential of tannins
9. Biological macromolecules as antidiabetic agents
10. Antidiabetic drugs from fungi
11. Antidiabetic secondary metabolites from marine source

Section 3: Pharmacological mechanism

12. Screening of antidiabetic drugs: in-vitro approaches
13. Animal models for screening of antidiabetic drugs from natural sources
14. Molecular Mechanisms of secondary metabolites as antidiabetic agents
15. Network pharmacology approach for antidiabetic drugs from natural sources

Section 4: Natural antidiabetics: Nature to clinic and market

16. Recent advances in natural antidiabetics
17. Antidiabetic drugs: Marketed formulations and case studies
18. Antidiabetic drugs: Patent case studies
19. Natural antidiabetic herbs and drug interactions