Caspases as Molecular Targets for Cancer Therapy

Auteur
Dr. Ankur Vaidya obtained his PhD from Dr. H.S. Gour University, when he researched design, synthesis, and screening of a few quinoline and oxadiazole derivatives for anticancer activities. He has 12 years of experience in teaching and research, and already supervised 18 PhD students. He wrote 5 book chapters and co-authored 2 books, including Nanotechnology Applications for Cancer Chemotherapy (Elsevier, 2020).

Texte du rabat

Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities. This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives. It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.

Contenu

1. Introduction to caspases, its function, mechanism, and classification
   Sushanta Bhattacharya, Shankar Gupta and Vivek Asati
   
   2. Mutations within apoptosis gene and caspases
      Manya Khurana, Paranjeet Kaur, Somdutt Mujwar, Manjinder Singh and Sanjeev Kumar Sahu
   3. Inflammatory caspase-1, -4, and -5 and their role in anticancer activity
      Ruchi Shakya, Navneesh, Shivanshu Pandey, Sumit Pasricha, Balak Das Kurmi and Preeti Patel
   4. Caspase-2 and tumor suppression
      Ravindra Kumar Chourasiya, Ankur Vaidya and Alok Nahata
   5. Caspase-3: A promising target for anticancer agents
      Sushmita Pandey, Shweta Jain, Sanjeev Sahu, Vinod Gurjar and Ankur Vaidya
   6. Caspase 7 mutations and their activators
      Sanjeev Kumar Sahu, Charanjit Kaur, Ankit Yadav, Yashraj Potale, Paranjeet Kaur, Shweta Jain and Ankur Vaidya
   7. Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy
      Vinod Kumar Gurjar, Shweta Jain, Ankur Vaidya and Kuldeep Bansal
   8. Caspase-9 gene mutation and its activators
      Ravichandran Veerasamy
   9. Caspases activity assay procedures
      Sourabh Satapathy, Shivam Kumar, Vaibhav Nigam, Balak Das Kurmi, Ankur Vaidya, Akash Ved and Preeti Patel
   10. Current and future prospective of caspases targeting in cancer therapy
       Disha Prabhu, Surendra Jain, Rakesh Chawala, Shweta Jain and Ankur Vaidya