Anion Channels and Transporters

This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

Describes mechanisms that ensure selective anion transport across biological membrane Illustrates the variability of cellular processes that are regulated by anion channels and transporters Explains how anion channel/transporter dysfunction can cause severe human diseases

Contenu
P reface.- Muscle chloride channels.- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism.- ClC-K Kidney Chloride Channels : from structure to pathology.- Biophysical and pharmacological insights to CLC chloride channels and Transporters.- Function and regulation of the calcium-activated chloride channel anoctamin 1.- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family.- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation.- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206.- CFTR modulators: from mechanism to targeted therapeutics.- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters.- SLC26 Anion Transporters.- Pharmacology of Na-dependent transporters of inorganic phosphate.- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport. <p