Animal Models of Acute Neurological Injuries

With contributions from leading experts and many original developers of models, this text provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field.

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.

Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Forty established animal models for acute neurological injury Special chapters on animal anesthesia, monitoring and tissue harvesting Step-by-step manual on all aspects of technical issues related to animal modeling Full color photographs on all key surgical steps Written by experts in each field and by the original developers of the animal models

Contenu
Animal Care and Surgery.- Animal Protocol.- Anesthesia and Analgesia for Research Animals.- Rodent Surgical Procedures and Tissue Collection.- Brain Monitoring.- Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies.- Cerebral Ischemic Animal Models.- Four-Vessel Occlusion Model in Rats.- Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia.- Asphyxial Cardiac Arrest.- Rodent Model of Pediatric Asphyxial Cardiac Arrest.- Transient Global Cerebral Ischemia Model in Mice.- Transient Middle Cerebral Artery Occlusion Model in Rodents.- Three-Vessel Middle Cerebral Artery Occlusion Model.- A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA.- Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption.- Middle Cerebral Artery Occlusion Suture Model for Mice.- Intraluminal Middle Cerebral Artery Occlusion Model in Mice.- Cerebral HypoxiaIschemiaModel in Adult Mice.- Cerebral HypoxiaIschemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury.- Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits.- Model of Neonatal Focal Cerebral Ischemia-Reperfusion.- Cerebral Hemorrhage Animal Models.- Monofilament Perforation Subarachnoid Hemorrhage Rat Model.- Blood Injection Subarachnoid Hemorrhage Rat Model.- Filament Perforation Subarachnoid Hemorrhage: Mouse Model.- Blood Injection Subarachnoid Hemorrhage Mouse Model.- Blood Injection Cerebral Vasospasm Rabbit Model.- Double Blood-Injection Cerebral Vasospasm Canine Model.- Nonhuman Primate Blood-Clot Placement Cerebral Vasospasm Model.- Blood Injection Intracerebral Hemorrhage Rat Model.- Bacterial Collagenase Injection Intracerebral Hemorrhage Rat Model.- Blood Injection Intracerebral Hemorrhage Mouse Model.- Blood Injection Intracerebral Hemorrhage Pig Model.- Traumatic CNS Injury Animal Models.- Fluid Percussion Injury Model.- Controlled Cortical Impact Injury Model.- Marmarou Weight Drop Injury Model.- MASCIS Spinal Cord Contusion Model.- Infinite Horizon Spinal Cord Contusion Model.- The Ohio State University ESCID Spinal Cord Contusion Model.- Acute Clip Impact-Compression Model.- Experimental Laceration Spinal Cord Injury Model.- Rodent Spinal Cord Demyelination Models.- Spinal Cord Lateral Hemisection and Implantation of Guidance Channels.- Spinal Root Avulsion and Repair Model.