Animal Cell Technology: Basic & Applied Aspects

Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells, but also to ascertain their abilities to be used for industrial and medical purposes. The goal of animal cell technology includes the clonal expansion of differentiated cells, the optimization of their culture conditions, modulation of their ability to produce proteins of medical and pharmaceutical importantance, and the application of animal cells to gene therapy, artificial organs and the production of functional foods. This volume gives the readers a complete review of the present state-of-the-art and will be useful for those working in either academic environments or in the biotechnology and pharmaceutical sectors, particularly cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and all other disciplines related to animal cell culture.

Gives readers a complete review of present state-of -the-art in animal cell technology in Japan and other countries Includes unique papers on animal cell technology from industrial fields which may not be published elsewhere Gives practical information on application of animal cell technology for the production of biomedicines Includes supplementary material: sn.pub/extras

Contenu
Non-fucosylated Therapeutic Antibodies: The Next Generation of Therapeutic Antibodies.- Selective Expansion of Genetically Modified T Cells Using a Chimeric IL-2 Receptor for Cancer Therapy.- Effects of Serum and Growth Factors on HEK 293 Proliferation and Adenovirus Productivity.- Simple and Efficient Establishment of Recombinant Protein Hyper-Producing Cells by Using RAS-Amplified CHO Cell Line.- Effects of Sericin on Promoting Proliferation and Inhibiting Apoptosis of Mammalian Cells.- Molecular Biological Analysis of Mitogenic and Anti-Apoptotic Mechanisms of Seric.- Novel Serum-Free Cryopreservation of Mammalian Cells Using Seric.- The Effect of Interleukin-6 and Leukemia Inhibitory Factor on Hybridoma Cells.- In-Situ Observation of a Cell Growth Using Surface Infrared Spectroscopy.- Scale-Down Perfusion Process for Recombinant Protein Expression.- Computer-Based Matrix to Evaluate Optimal Medium Delivery Format for Biopharmaceutical Production.- A Serum Substitute for Fed-Batch Culture of Hybridoma Cells.- Effects of Sugar Chain Precursors on Recombinant Protein Production in BHK Cells.- Promoting Non-Hematopoietic Cell Proliferation by Chimeric Receptors.- Efficient Acquisition of Antigen-Specific Human Monoclonal Antibody by Using Peripheral Blood Mononuclear Cells Immunized In Vitro.- Immunomodulatory Effects of Orally Administered Bifidobacterium Components on Intestinal Lymphoid Tissues.- Murine Intestinal Bacteria Modulate Antigen-Specific Cytokine Production by Intestinal Immune Cells Derived from Germ-Free TCR-Transgenic Mice.- Spleen Cells Derived from Male Non-Obese Diabetic Mice are Capable of Suppressing the Autoantigen-Specific Production of Interferon-? of Female Cells In Vitro.- Highly Efficient Antibody Production by Improving Cell Survival UsingSeric.- Generation of Human Monoclonal Antibody Specific for Propionibacterium Acnes by In Vitro Immunization.- Construction of Multi-layered Cell Sheet Using Magnetite Nanoparticles and Magnetic Force.- Anti-histone H1 Autoantibody: An Inducible Immunosuppressive Factor in Liver Transplantation.- Anti-histone H1 Autoantibody Directly Acts on T Cells to Exert Its Immunosuppressive Activity.- The Effect of Culture Conditions on Liver Function and Proliferation of Hepatic Cells for Bio-Artificial Liver.- The Effect of Scaffold on the Morphology and Insulin Secretion of Islet Cells.- Sterilization of Chicken Primordial Germ Cells.- Protein Expression by Human Intestinal Epithelial Cells in Response to Wastewater Constituents.- In Vitro Cytotoxic Effects of Tin Compounds on Normal Human Astrocytes.- Effects of Tin Compounds on Human Chondrogenic Activity In Vitro.- Construction of a Fluorescein-Responsive Chimeric Receptor with Strict Ligand Dependency and Analysis of the Role of Erythropoietin Receptor Domains in Signal Transduction.- Nuclear Structures Regulate Liver-Specific Expression of the Tryptophan Oxygenase Gene.- CCAAT/Enhancer-Binding Protein Beta Controls Differentiation-Specific Expression of Chromatin Remodeling Factor BRM.- Involvement of 67 kDa Laminin Receptor on Cellular Uptake of Green Tea Polyphenol Epigallocatechin-3-O-Gallate in Caco-2 Cells.- Inositol Derivatives Stimulate Glucose Transport in Muscle Cells.- Hair Growth Regulation by an Aromatic Plant Extract.- Screening of Various Tunisian Olive Oils for Their Inhibitory Effect on Beta-Hexosaminidase Release by Basophilic Cells.- Leaf Extracts from Tunisian Olive Cultivars Induce Growth Inhibition and Differentiation of Human Leukemia HL-60 Cells.- In Vitro Observation of the Effect of Intestinal Bacteria on IgA Production by Immunocytes in the Large Intestine: Comparison Between Germ-Free and Conventional Mice.- Differentiation of Human Leukemia Cell Line HL-60 by a Polyacetylenic Compound from Hedera Rhombea.- Effect of Tunisian Plant Extract on Melanogenesis.- Nordenau Phenomenon Application of Natural Reduced Water to Therapy.- Anti-melanogenic Activity of Ergosterol Peroxide from Ganoderma lucidum on a Mouse Melanoma Cell Line.- Differentiation-Inducing Activities by Lupane Triterpenes from Lactuca indica on a Mouse Melanoma Cell Line.- Immunoglobulin Production Stimulating Effect of Soy-Derived Proteins.- Immunostimulation Effect of the Jellyfish Collagen.- Mycotoxin Nivalenol Induces Apoptosis and Intracellular Calcium Ion-Dependent Interleukin-8 Secretion but Does Not Exert Mutagenicity.- Development of an In Vitro System for Screening the Ligands of a Membrane Glycoprotein CD36.- MTT Reduction by Flavonoids in the Absence of Cells: Influence of Medium Type and Serum.- Characterization of Highly Reactive Sequences for Transglutaminase 2 and Factor XIIIa.- Some Characteristics of UNC-51 Phosphorylations of Both Actins and Tubulins.- Protein Phosphotase 1? Reverses UNC-51 Phosphorylations of Both Actins and Tubulins and a New Model of UNC-51-Inducing Axon Formation.- Overexpression of Conserved Kinase UNC-51 Inhibits the Transferrin's Endocytosis into the Mammalian Cells.