Nanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy

This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery.

Provides a detailed overview of applications of nanomaterials in molecular imaging, diagnosis, and therapy Details the synthesis and application of biocompatible fluorescent nanomaterials Presents the current understanding of the formation of biomolecular coronas and their potential implications in nanomedicine Critically reviews the challenges and future prospects of nanomedicine

Auteur

Dr. Amitabha Acharya is a Senior Scientist at the Nanobiology Laboratory, Biotechnology Division, CSIR-IHBT, Palampur. He graduated in Chemistry (Hons.) from the University of Calcutta, India, completed his postgraduate studies in Inorganic Chemistry at Banaras Hindu University, India, and received his Ph.D. degree in the area of Chemical Nanotechnology and Nanobiology from IIT Bombay under the supervision of Prof. C. P. Rao. His current research focuses on the synthesis and characterization of functional nanomaterials for molecular imaging, probe development, biomedical applications of nanomaterials against biofilm activity, the development of nano-chaperons as protein aggregation inhibitors, and understanding nanoparticle-cell/protein interactions. His contributions in the area include the development of novel carbon nanomaterials from Himalayan bioresources and the identification of key proteins responsible for protein corona formation under physiological conditions. He has published over 18 research articles and 4 review articles in peer-reviewed international journals and authored or co-authored 4 book chapters. He also holds three patents. Early in his career, he passed the GATE examination in India (AIR 129), and was a recipient of JRF and SRF fellowships from CSIR, India. He later received a Dr. D.S. Kothari postdoctoral fellowship. He has served as reviewer for several journals and is a life member of several scientific societies and organizations.

Contenu
Chapter 1. Nanomaterials: From research to personalized medicine.- Chapter 2. Introduction to molecular imaging, diagnostics and therapy.- Chapter 3. Biocompatible fluorescent nanomaterials for molecular imaging applications.- Chapter 4. Nanomaterials for Point of Care Disease Detection.- Chapter 5. Biomolecules immobilized nanomaterials and their biological applications.- Chapter 6. Lectin nanoconjugates for targeted therapeutic applications.- Chapter 7. Plant Based Polymeric Nanomaterials for Biomedical Applications.- Chapter 8. Nanomaterials at the biological interphase: Protein corona formation and infusion.- Chapter 9. Critical overview of the subject: Current scenario and future prospects.