Adenoviral Vectors for Gene Therapy

Texte du rabat

Adenoviral Vectors for Gene Therapy, Third Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

The fully updated and expanded third edition covers the basic biology of adenoviruses, highlights the potential use adenoviral vectors for the treatment of disease including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for vet applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine application and virotherapy, and oncolytic adenoviruses for anti-tumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Contenu

1. Adenovirus Structure
   
   2. Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms
   3. Adenovirus Replication
   4. Adenoviral Vector Construction I: Mammalian Systems
   5. Adenoviral Vector Construction II: Bacterial Systems
   6. Upstream Bioprocess for Adenovirus Vectors
   7. Propagation of Adenoviral Vectors: Use of PER.C6(TM) Cells
   8. Purification of Adenovirus
   9. Targeted Adenoviral Vectors I: Transductional Targeting
   10. Targeted Adenoviral Vectors III: Transcriptional Targeting
   11. Adenoviral Vector Targeting via Mitigation of Liver Sequestration
   12. Molecular Design of Oncolytic Adenoviruses
   13. Conditionally Replicative Adenoviruses-Clinical Trials
   14. Innate Immune Response to Adenovirus Vector Administration In Vivo
   15. Antibodies against Adenoviruses
   16. Methods to Mitigate Immune Responses to Adenoviral Vectors
   17. Helper-Dependent Adenoviral Vectors
   18. Hybrid Adenoviral Vectors
   19. Xenogenic Adenoviral Vectors
   20. Engineering Chimeric Adenoviruses: Exploiting Virus Diversity for Improved Vectors, Vaccines, and Oncolytics
   21. Adenoviral Vector Vaccines Antigen Transgene
   22. Adenoviral Vectors Vaccine: Capsid Incorporation of Antigen
   23. Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer
   24. In Situ Vaccination with Adenoviral Vectors to Treat Cancer
   25. Utility of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease
   26. Adenoviral Vectors for Pulmonary Disease (Pulmonary Vascular Disease)
   27. Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases
   28. Animal Models of Gene Therapy for Cardiovascular Disease
   29. Polymer-Anchored Adenovirus as a Therapeutic Agent for Cancer Gene Therapy
   30. Adenoviral Vectors for RNAi Delivery
   31. Imaging and Adenoviral Gene Therapy
   32. Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective