Acute Pancreatitis

This book is an accessible, evidence-based, succinct and practical reference for those providing hands-on care to patients with acute pancreatitis. It represents the most updated results of clinical science and offers the frameworks that underpin the disease and its management. The first part of the book presents the latest clinical science and illustrates a clear indication of what is known, and what are the gaps in our understanding of the disease. The second part provides practical clinical management guidelines. The chapters are designed to bring recommendations, practical points to facilitate navigation, easy access of knowledge, and highlights key decision points and options.

Acute Pancreatitis - A Practical Guide for Clinicians is relevant to not only clinicians involved in patient care but medical, nursing and dietitian students, surgical and gastroenterology researchers, companies and agencies.

The book comprehensively covers acute pancreatitis, associating it with local pancreatic complications, systemic inflammation and organ failures, also providing management algorithms. This practical reference book is an introduction to disease management, indicating why topics addressed in each chapter are essential, providing valuable guidance for day-to-day treatment by professionals globally.

An accessible, evidence-based, practical reference for those providing hands-on care to patients with acute pancreatitis Presents a clear indication of what is and is not currently known and makes a recommendation to patient management Associates the disease with local pancreatic complications, systemic organ failures, and provides management algorithms

Auteur

Prof. John Windsor grew up in the Indian Himalayas, did surgical training in New Zealand and specialist HBP training in Edinburgh. Professor of Surgery and Director of Surgical and Translational Research Centre, University of Auckland. HBP and Upper GI Surgeon at the Auckland City and Mercy Hospitals. Fellow of ANZ, American and Edinburgh Colleges of Surgeons. Yeoh Ghim Seng Professor at National University of Singapore. Has been Secretary General of International Hepato-Pancreato-Biliary Association and Chair Section of Academic Surgery in the RACS. For 30 years he has been active in promoting research and education, especially the training of surgeon scientists. His surgical interests include the management of acute and chronic pancreatitis, pancreatic cancer, and gastro-oesophageal reflux and cancer. His research includes pathophysiology of acute pancreatitis, the role of toxic mesenteric lymph in critical illness and the mapping and modulation of gastric electrical activity. He has published widely with a GS H-index of 77. He is on the editorial board of JAMA Surgery, British Journal Surgery and Pancreatology. National chair of HBP tumour stream for Ministry of Health. Awarded Gluckman Medal for distinguished research contributions at the University of Auckland, the Sir Louis Barnett Medal for distinguished contributions to the RACS and elected Fellow of the American Surgical Association, James IV Association and the Royal Society of New Zealand.

Associate Professor S. George Barreto grew up in Goa (India) where he did his surgical training before completing Fellowships in HBP surgical oncology at the Tata Memorial Centre (Mumbai) and Liver transplant at the Flinders Medical Centre (Adelaide). Consultant HPB and Liver Transplant Surgeon, Flinders Medical Centre, and Deputy Director and Coordinator of Advanced Studies, Flinders Medical Program, Flinders University, South Australia. Fellow of the Association of Surgeons of India and the Royal Australasian College of Surgeons. From developing the technique of isolating murine pancreatic fragments to study pancreatic exocrine secretion to using them to understand the effects of neuropeptides on pancreatic exocrine secretion and the pathogenesis of acute pancreatitis; from employing an objective approach to auditing and evaluating his own practice of pancreatic surgery to improve not only the technique of surgery but the quality of cancer surgery care delivered to his patients, A/Prof. Barreto has contributed to the advancement of science, especially in diseases of the pancreas, namely acute pancreatitis and pancreatic cancer. His research interests include deciphering the pathophysiology, epidemiological burden and management of acute pancreatitis and pancreatic cancer, as well as studying the rapidly increasing problem of young-onset cancers. He has published over 290 peer-reviewed papers and chapters and has a GS H-index of 40. He is the Associate Editor of the World Journal of Surgery and the Indian Journal of Surgery and is on the editorial boards for Scientific Reports and Pancreatology. A/Prof. Barreto has edited two books on pancreato-biliary and abdominal surgery. He has served, and continues to serve, on national and international committees involved in the development of guidelines for the management of pancreatic cancer, gallbladder cancer and neuroendocrine tumors.

Professor Anthony Phillips is a multidisciplinary, surgical research scientist based at the University of Auckland (UoA) in New Zealand (NZ). Anthony began his academic career with a biochemistry and chemistry degree from Victoria University, Wellington, NZ before he undertook his medical studies at the University of Otago, Dunedin, NZ graduating with Distinction. After a series of clinical positions he undertook a PhD in pancreatology at the University of Auckland, before developing a formal research career in surgical science. He remains a registered medical practitioner with his main activity focused on undertaking applied and translational surgical research during which he has developed a diverse array of interests and skills. He established the Applied Surgical and Metabolism Laboratory at the UoA to provide dedicated basic science facilities for surgical trainees to undertake doctoral level research. A major thematic research focus has been understanding the onset of critical illness and multiple organ failure as typified by acute pancreatitis. Anthony has a particular interest in translational medicine. He has served as the Preclinical Director, Medical Director, CEO and CTO for a range of biotechnology companies, during which time he has supervised a wide range of clinical and preclinical basic science studies. He has been the recipient of the a number of University research excellence awards. Anthony serves on various NZ grant committees and has authored over 200 basic and applied medical science publications, as well as previously contributed to pancreatic science text book chapters.

Contenu

Section I Clinically Relevant Science.- 1. Epidemiology including aetiology / natural history / risk factors including obesity / mortality / sequelae (recurrence, diabetes, PEI).- 2. Genetic factors in acute pancreatitis.- 3. Initiating cellular events in acute pancreatitis.- 4. Pathophysiology of local complications.- 5. Mechanisms in systemic inflammation.- 6. Mechanisms in organ dysfunction/failure.- Section II Clinical Management.- 7. Prevention and ERCP pancreatitis.- 8. Diagnosis and Severity (prediction/assessment.- 9. Pain and analgesia.- 10. Fluids and resuscitation.- 11. Nutritional support.- 12. Antibiotics and probiotics.- 13. Managing biliary pancreatitis.- 14. Managing hyperlipidaemic pancreatitis.- 15 Managing idiopathic pancreatitis.- 16. Managing local complications (timing and techniques).- 17. Managing organ dysfunction/failure.