Medical Pharmacology and Therapeutics

Autorentext

Derek G. Waller, BSc, DM, MBBS, FRCP, Consultant Cardiovascular Physician, Southampton General Hospital; Senior Lecturer in Medicine and Clinical Pharmacology, University of Southampton, Southampton, UK

Klappentext

Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA. This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class. Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines. A clinical focus throughout - suitable for medical, nursing and other healthcare students throughout their training Thorough update of clinically-relevant medicines to ensure best practice Information aligned with the British National Formulary (BNF), NICE guidelines and relevant professional benchmarks Comprehensive drug compendia allow all drugs to be identified and placed within their respective classes Extensive self-assessment questions to support learning and revision New to this edition Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19 Expanded discussion of the pathophysiology and management of shock Revised discussion of the management of chronic pain Consideration of treatment of Covid-19

Inhalt

Preface

Drug Dosage and Nomenclature

SECTION 1 GENERAL PRINCIPLES

1. Principles of Pharmacology and Mechanisms of Drug Action

2. Pharmacokinetics

3. Drug Discovery, Safety and Efficacy

4. Neurotransmission and the Peripheral Autonomic Nervous System

SECTION 2 THE CARDIOVASCULAR SYSTEM

5. Ischaemic Heart Disease

6. Systemic and Pulmonary Hypertension

7. Heart Failure and Shock

8. Cardiac Arrhythmias

9. Cerebrovascular Disease and Dementia

10. Peripheral Artery Disease

11. Haemostasis

SECTION 3 THE RESPIRATORY SYSTEM

12. Asthma and Chronic Obstructive Pulmonary Disease

13. Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome

SECTION 4 THE RENAL SYSTEM

14. Diuretics

15. Disorders of Micturition

16. Erectile Dysfunction

SECTION 5 THE NERVOUS SYSTEM

17. General Anaesthetics

18. Local Anaesthetics

19. Opioid Analgesics and the Management of Pain

20. Anxiety, Obsessive-Compulsive Disorder and Insomnia

21. Schizophrenia and Bipolar Disorder

22. Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy

23. Seizures and Epilepsy

24. Extrapyramidal Movement Disorders and Spasticity

25. Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain-Barré

Syndrome

26. Migraine and Other Headaches

SECTION 6 THE MUSCULOSKELETAL SYSTEM

27. The Neuromuscular Junction and Neuromuscular Blockade

28. Myasthenia Gravis

29. Nonsteroidal Anti-inflammatory Drugs

30. Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis

31. Hyperuricaemia, Gout and Pseudogout

SECTION 7 THE GASTROINTESTINAL SYSTEM

32. Nausea and Vomiting

33. Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease

34. Inflammatory Bowel Disease

35. Constipation, Diarrhoea and Irritable Bowel Syndrome

36. Liver Disease

37. Obesity

SECTION 8 THE IMMUNE SYSTEM

38. The Immune Response and Immunosuppressant Drugs

39. Antihistamines and Allergic Disease

SECTION 9 THE ENDOCRINE SYSTEM AND METABOLISM

40. Diabetes Mellitus

41. The Thyroid and Control of Metabolic Rate

42. Calcium Metabolism and Metabolic Bone Disease

43. Pituitary and Hypothalamic Hormones

44. Corticosteroids (Glucocorticoids and Mineralocorticoids)

45. Female Reproduction

46. Androgens, Antiandrogens and Anabolic Steroids

47. Anaemia and Haematopoietic Colony-Stimulating Factors

48. Lipid Disorders

SECTION 10 THE SKIN AND EYES

49. Skin Disorders

50. The Eye

SECTION 11 CHEMOTHERAPY

51. Drugs for Infections

52. Drugs for Cancer

SECTION 12 GENERAL FEATURES, TOXICITY AND PRESCRIBING

53. Drug Toxicity and Overdose

54. Substance Abuse and Dependence

55. Prescribing, Adherence and Information About Medicines

56. Drug Therapy in Special Situations

Index