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The definitive textbook on the chemical analysis of pharmaceutical drugs -- fully revised and updated
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics
Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject
Examines various analytical techniques commonly used in pharmaceutical laboratories
Provides practice problems, up-to-date practical examples and detailed illustrations
Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines
Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.
Autorentext
STIG PEDERSEN-BJERGAARD is Professor at the Department of Pharmacy, University of Oslo and Professor at the Department of Pharmacy, University of Copenhagen. BENTE GAMMELGAARD is Professor at the Department of Pharmacy, University of Copenhagen. TRINE GRØNHAUG HALVORSEN is Associate Professor at the Department of Pharmacy, University of Oslo.
Klappentext
The definitive textbook on the chemical analysis of pharmaceutical drugs fully revised and updated Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals. This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved full-colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
Zusammenfassung
The definitive textbook on the chemical analysis of pharmaceutical drugs fully revised and updated
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
Inhalt
Preface to the Second Edition xv
Abbreviations xvii
Symbols and Units xxi
1 Introduction to Pharmaceutical Analytical Chemistry 1
1.1 Introduction 1
1.2 Pharmaceutical Analytical Chemistry 4
1.3 This Textbook 7
2 Marketing Authorizations, Pharmaceutical Manufacturing, and International Pharmacopoeias 9
2.1 Introduction 9
2.2 Marketing Authorization and Industrial Production 10
2.3 Pharmacopoeias 13
2.4 Life Time of Pharmaceutical Preparations and Ingredients 14
3 Fundamentals of Bases, Acids, Solubility, Polarity, Partition, and Stereochemistry 17
3.1 Acids, Bases, pH, and pKa 17
3.2 Buffers 19
3.3 Acid and Base Properties of Drug Substances 20
3.4 Distribution Between Phases 21
3.5 Stereoisomers 26
3.6 Active Pharmaceutical Ingredients A Few Examples 28
3.7 Stability of Drug Substances 34
4 Fundamentals of Pharmaceutical Analytical Chemistry 37
4.1 Pharmaceutical Analytical Chemistry 37
4.2 How to Specify Quantities, Concentrations, and Compositions of Mixtures 39
4.3 Laboratory Equipment 43
4.4 How to Make Solutions and Dilutions 52
4.5 Errors, Accuracy, and Precision 54
4.6 Statistical Tests 56
4.7 Linear Regression Analysis 65
4.8 How to Present an Analytical Result 68
…