Nutrition in Epigenetics

The study of epigenetics, or how heritable changes in gene
expression are regulated without modifying the coding DNA sequence,
has become an increasingly important field of study in recent
years. Rapid developments in our understanding of the way in which
gene function is modulated by the environment has revolutionized
the way we think about human development and health. Nutrition
in Epigenetics reviews the latest research looking at the
interaction between genes and nutrients and the role they play
together in maintaining human health.

Nutrition in Epigenetics is divided into two primary
parts. The first part provides key principles such as epigenetic
mechanisms, developmental epigenetics, and the role of epigenetics
in disease. The second part looks specifically at the application
of epigenetics to the field of human nutrition. Chapters review the
role of specific nutrients in modulating epigenetic status and the
effect on health and disease.

Nutrition in Epigenetics is an indispensable resource for
researchers, professionals and advanced students with an interest
in human nutrition, epigenetics, and biomedical research.

Autorentext

Mihai D. Niculescu is an Assistant Professor of Nutrition at
the University of North Carolina's Gillings School of Global
Public Health in Chapel Hill, and at the UNC Nutrition Research
Institute in Kannapolis, North Carolina, USA.

Paul Haggarty is Head of the Lifelong Health Programme,
and the Nutrition and Epigenetics Group, at the Rowett Institute of
Nutrition and Health in the University of Aberdeen in Aberdeen,
Scotland.

Zusammenfassung
The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease.

Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Inhalt

Contributors vii

1. Introduction 1
   Mihai D. Niculescu and Paul Haggarty

Part I: Fundamental Principles in Epigenetics

**Section A: Epigenetic Mechanisms

2. DNA Methylation 13
   Natalia V. Cucu

3. Chromatin Modifications 47
   Sandra B. Hake

4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic Processes 73
   Muller Fabbri

5. Epigenetic Inheritance: Both Mitotic and Meiotic 87
   Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw

Section B: Development Epigenetics

6. Developmental Epigenetics: Roles in Embryonic Development 107
   Liliana Burlibas¸a and Lucian Gavril**a

Section C: Epigenetic Mechanisms in Disease

7. Epigenetics, Nutrition, and Cancer 129
   Amy R. Johnson

8. Metabolic Syndrome, Obesity, and Diabetes 145
   Karen D. Corbin

9. Autoimmunity 165
   Donna Ray and Raymond Yung

10. Cardiovascular Diseases 173
    Aurelian Bidulescu and Methode Bacanamwo

Part II: Nutritional Status and Specific Nutrients

Section A: Maternal Nutrition and Fetal Development

11. Maternal Nutrition and Developmental Outcomes 193
    Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore

Section B: Role of Specific Nutrients

12. Folate, Vitamin B12, and Vitamin B6 211
    Patrick J. Stover

13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development 225
    Steven H. Zeisel

14. Epigenetic Regulation by Retinoids 241
    Amandio Vieira

15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome 249
    Carlos M. Guerrero-Bosagna and Susan J. Clark

16. Isothiocyanates and Polyphenols 263
    Nigel J. Belshaw and Ian T. Johnson

Section C: Macronutrient Intakes

17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation 275
    Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge

Section D: Environmental Exposures

18. Epigenetic Manifestation of Environmental Exposures 289
    Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek

Section E: Epidemiology of Nutritional Epigenetics

19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences 311
    Paul Haggarty

20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329
    Audrey Jung and Ellen Kampman

Index 345