Nutraceuticals and Natural Product Derivatives

Introduces readers to the growing applications of nutraceuticals and other natural product derivatives

This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population.

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer's disease; the therapeutic potential of metalloherbal nanoceuticals; and much more.

• Offers an alternative, natural approach to the prevention of chronic diseases

• Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies

• Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention

• Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Autorentext

About the Editors Mohammad Fahad Ullah, is an Assistant Professor of Biochemistry in the Department of Medical Laboratory Technology (FAMS) and a Research Scientist at Prince Fahd Research Chair, University of Tabuk, Saudi Arabia. Aamir Ahmad, is an Assistant Professor of Oncologic Sciences at University of South Alabama's Mitchell Cancer Institute, Mobile, AL, USA.

Inhalt
List of Contributors xvii

Foreword xxi

Preface xxv

Books Description xxix

Expert Commentary xxxi

**1 Natural Food Sources for the Control of Glycemia and the Prevention of Diabetic Complications 1
**Carlo Pesce, Carla Iacobini, and Stefano Menini

1.1 Introduction: Obesity, Metabolic Syndrome, and Type 2 Diabetes Epidemics: The Role of Nutrition 1

1.2 Phytochemicals of Nutraceutical Importance and Functional Foods of Plant Origin 3

1.2.1 Dietary Oils 3

1.2.2 Vegetables and Fruits 4

1.3 Nutraceuticals and Functional Foods of Animal Origin 8

1.3.1 The Case of Carnosine 8

1.4 Nutraceuticals of Both Plant and Animal Origin 9

1.5 Probiotics, Prebiotics, and Symbiotics 12

1.6 Conclusion 15

References 17

**2 AntiAging Effects of SulfurContaining Amino Acids and Nutraceuticals 25
**Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, and Syed Ibrahim Rizvi

2.1 Aging and Nutrition 25

2.2 Natural Antioxidants 26

2.2.1 SulfurContaining Amino Acids and Their Role as Antioxidants 26

2.2.2 AntiAging Effects of LCysteine 27

2.3 NAcetylLCysteine 28

2.3.1 Neuroprotective Effects of NAcetylLCysteine 29

2.3.2 NAcetylLCysteine in Combination with Other Antioxidants 29

2.4 Methionine 30

2.4.1 Methionine Restriction 30

2.5 SulfurContaining Nutraceuticals and Foods Rich in SulfurContaining Amino Acids 31

2.5.1 Whey Protein 32

2.5.2 AntiAging Effects of Whey Protein 32

2.6 Conclusion 33

Acknowledgments 33

Conflict of Interest 33

References 33

**3 Garcinia Fruits: Their Potential to Combat Metabolic Syndrome 39
**Oliver John, Lindsay Brown, and Sunil K. Panchal

3.1 Introduction 39

3.2 Overview of Compounds in Garcinia Species 40

3.2.1 Garcinia mangostana 44

3.2.1.1 Chemical Properties 51

3.2.1.2 Biological Activities of G. mangostana 51

3.2.1.3 Toxicity 55

3.2.2 Garcinia cambogia 56

3.2.2.1 Chemical Properties 56

3.2.2.2 Biological Activities 57

3.2.2.3 Toxicity 59

3.2.2.4 Future Research 59

3.2.3 Garcinia humilis 59

3.2.3.1 Chemical Properties 59

3.2.3.2 Biological Activities 60

3.2.4 Garcinia dulcis 61

3.2.4.1 Chemical Properties 61

3.2.4.2 Biological Properties 61

3.2.4.3 Potential Research 62

3.3 Limitations 62

3.4 Conclusion 64

References 64

**4 ProAngiogenic and AntiAngiogenic Effects of Small Molecules from Natural Products 81
**Jingyi Ma and Xuelin Zhou

4.1 Biological mechanisms of Angiogenesis 81

4.2 Pharmacological Models for Angiogenesis Study 82

4.3 ProAngiogenic Effects of Small Molecules from Natural Products 83

4.3.1 Natural Products as Sources for Screening ProAngiogenic Stimulators 83

4.3.2 Flavonoids 84

4.3.3 Saponins 84

4.3.4 Salvianolic Acids 85

4.3.5 Other Small Molecules 85

4.3.5.1 Ferulic Acid 85

4.3.5.2 Aloe veraDerived Compounds 85

4.3.6 Summary 86

4.4 AntiAngiogenic Effects of Small Molecules from Natural Products 86

4.4.1 Natural Products as Sources for Screening Angiogenic Inhibitors 87

4.4.2 Flavonoids 87

4.4.3 Diterpenoids 89

4.4.4 Polyphenol 90

4.4.5 Saponins 92

4.4.6 Alkaloids 93

4.4.7 Chalcone 93

4.4.8 Anthraquinone 93

4.4.9 Carotenoids 94

4.4.10 Other Small Molecules 94

4.4.10.1 Cucurbitacin B 94

4.4.10.2 Honokiol 95

4.4.10.3 Shikonin 95

4.4.10.4 Hyperforin 95

4.4.10.5 Glyceollins 95

4.4.10.6 Sulforaphane 99 4.4.11 Summary 99...