Deep Brain Stimulation

Deep brain stimulation (DBS) is a widely used therapy for movement disorders such as Parkinson's disease, essential tremor, and dystonia. Its therapeutic success has led to the application of DBS for an increasing spectrum of conditions. However, the fundamental relationships between neural activation, neurochemical transmission, and clinical outcomes during DBS are not well understood.Drawing on the clinical and research expertise of the Mayo Clinic Neural Engineering Laboratories, this book addresses the history of therapeutic electrical stimulation of the brain, its current application and outcomes, and theories about its underlying mechanisms. It reviews research on measures of local stimulation-evoked neurochemical release, imaging research on stimulation-induced neural circuitry activation, and the state of the art on closed-loop feedback devices for stimulation delivery.

Autorentext

Kendall H. Lee is a stereotactic and functional neurosurgeon at Mayo Clinic with internationally recognized expertise in deep brain stimulation. His MD and PhD are from Yale University. He is a professor in the Departments of Neurosurgery, Physiology & Biomedical Engineering, and Physical Medicine and Rehabilitation. He is director of the Neural Engineering Laboratories, focused on understanding the mechanisms of action of DBS and developing novel devices for neuromodulation.

Penelope S. Duffy is an associate director of the Neural Engineering Laboratories at Mayo Clinic with a PhD from the University of Minnesota. Dr. Duffy had a 27-year research and clinical career in neurologically based communication disorders and is the author of a graduate textbook on right hemisphere cognitive impairments. She has scientific papers in that area and in deep brain stimulation, and two books in the trade press.

Allan J. Bieber is an associate professor of Neurologic Surgery, associate director of the Neural Engineering Laboratories and of the Neurobiology of Disease Graduate Program in the Mayo Clinic College of Medicine. His PhD is in cellular and developmental biology from Harvard Medical School.

Inhalt

Overview of the History and Application of Deep Brain Stimulation
***Kendall H. Lee, Penelope S. Duffy, and Charles D. Blaha

***Biophysical Fundamentals of Neural Excitation
***Susanne Loffler and J. Luis Luján

***Motor Circuit Activity in Parkinson's Disease
***Allan J. Bieber

***Neuroimaging in Deep Brain Stimulation
***Hoon-Ki Min, Erika Ross, and Megan Settell

***Ethical Considerations in the Use of Deep Brain Stimulation
***Alexander Fiksdal, Osama A. Abulseoud, and Richard R. Sharp

***CLINICAL APPLICATIONS

Deep Brain Stimulation for Parkinson's Disease
***Bryan T. Klassen

***Deep Brain Stimulation for Tremor
***Andrea C. Adams

***Deep Brain Stimulation for Dystonia
***Nicholas D. Child and Bryan T. Klassen

***Deep Brain Stimulation for Obsessive-Compulsive Disorder
***Prakriti Gaba and Charles D. Blaha

***Deep Brain Stimulation for Touret te's Syndrome
***Hoon-Ki Min, Megan Settell, and Paola Testini

***Deep Brain Stimulation for Treatment-Resistant Depression
***Yesul Kim, Katheryn M. Wininger, and Susannah J. Tye

***Deep Brain Stimulation for Chronic Pain
***Grant W. Mallory and Prakriti Gaba

***Deep Brain Stimulation for Medically Refractory Epilepsy
***William S. J. Gibson and Penelope S. Duffy

***Deep Brain Stimulation for Memory Dysfunction
***Erika K. Ross, Kevin F. Bieniek, and Hoon-Ki Min

***Deep Brain Stimulation for Cluster Headache
***Cong Zhi Zhao

***Functional Electrical Stimulation for the Treatment of Spinal Cord Injury
***Peter J. Grahn, Aldo A. Mendez Ruiz, Jan T. Hachmann, and J. Luis Luján

***RESEARCH ON MECHANISMS OF DBS AND NEUROMODULATION

Theories of Deep Brain Stimulation Mechanisms
***Charles D. Blaha

***The Role of Astrocytes in Deep Brain Stimulation
***Su-Youne Chang and Kendall H. Lee

***Electrochemical Measurement of Neurochemical Concentrations
***Kevin E. Bennet, Charles D. Blaha, and Kendall H. Lee

***Electrodes for Neural Stimulation and Monitoring
***Jonathan R. Tomshine and Kevin E. Bennet

***Closed-Loop Control Systems for Deep Brain Stimulation Therapy
***James K. Trevathan and J. Luis Lujan

***Molecular and Cellular Neuromodulation for Central Nervous System Injury and Regeneration
***Lucas P. Carlstrom

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