Advanced Healthcare Materials

Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications

Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology.

The senior researchers from global knowledge centers have written topics including:

• State-of-the-art of biomaterials for human health

• Micro- and nanoparticles and their application in biosensors

• The role of immunoassays

• Stimuli-responsive smart nanoparticles

• Diagnosis and treatment of cancer

• Advanced materials for biomedical application and drug delivery

• Nanoparticles for diagnosis and/or treatment of Alzheimers disease

• Hierarchical modelling of elastic behavior of human dental tissue

• Biodegradable porous hydrogels

• Hydrogels in tissue engineering, drug delivery, and wound care

• Modified natural zeolites

• Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane

• Polyhydroxyalkanoate-based biomaterials

• Biomimetic molecularly imprinted polymers

Autorentext

Ashutosh Tiwari is an Associate Professor at the
Biosensors and Bioelectronics Centre, Linköping University,
Sweden; Editor-in-Chief, Advanced Materials Letters;
Secretary General, International Association of Advanced Materials;
a materials chemist and also a docent in applied physics at
Linköping University, Sweden. He has published more than 350
articles, patents, and conference proceedings in the field of
materials science and technology and has edited/authored more than
fifteen books on the advanced state-of-the-art of materials
science. He is a founding member of the Advanced Materials World
Congress and the Indian Materials Congress.

Inhalt

Preface xvii

1 **Stimuli-Responsive Smart Nanoparticles for Biomedical Application 1
*Arnab De, Sushil Mishra and Subho Mozumdar

• 1.1 A Brief Overview of Nanotechnology 2

  1.2 Nanoparticulate Delivery Systems 3

  1.3 Delivery Systems 4

  1.4 Polymers for Nanoparticle Synthesis 11

  1.5 Synthesis of Nanovehicles 15

  1.6 Dispersion of Preformed Polymers 16

  1.7 Emulsion Polymerization 20

  1.8 Purification of Nanoparticle 22

  1.9 Drying of Nanoparticles 24

  1.10 Drug Loading 25

  1.11 Drug Release 26

  1.12 Conclusion 27

  References 27

  2 Diagnosis and Treatment of CancerWhere We Are **and Where We Have to Go! 35
  *Ra*jiv *Lochan Gaur and Richa Srivastava

• 2.1 Cancer Pathology 36

  2.2 Cancer Diagnosis 37

  2.3 Treatment 41

  Conclusion 42

  References 42

  3 Advanced Materials for Biomedical Application and **Drug Delivery 47
  Salam J.J. *Titinchi,* *Mayank P.* *Singh, Hanna S. Abbo and Ivan R. Green

• 3.1 Introduction 48

  3.2 Anticancer Drug Entrapped Zeolite Structures as Drug Delivery Systems 48

  3.3 Mesoporous Silica Nanoparticles and Multifunctional Magnetic Nanoparticles in Biomedical Applications 52

  3.4 BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications 64

  3.5 Conclusions 75

  References 75

  4 Nanoparticles for Diagnosis and/or Treatment of **Alzheimer's Disease 85
  S.G. Antimisiaris, S. Mourtas, E. Markoutsa, A. Skouras, *and K. Papadia

• 4.1 Introduction 85

  4.2 Nanoparticles 86

  4.3 Physiological Factors Related with Brain-Located Pathologies: Focus on AD 96

  4.4 Current Methodologies to Target AD-Related Pathologies 110

  4.5 Nanoparticles for Diagnosis of AD 136

  4.6 Nanoparticles for Therapy of AD 146

  4.7 Summary of Current Progress and Future Challenges 160

  Acknowledgments 161

  References 161

  5 Novel Biomaterials for Human Health: Hemocompatible Polymeric Micro-and Nanoparticles and Their **Application in Biosensor 179
  *Chong Sun, Xiaobo Wang, Chun Mao and Jian Shen

• 5.1 Introduction 179

5.2 Design and Preparation of Hemocompatible Polymeric Micro- and Nanoparticles 181

5.3 The Biosafety and Hemocompatibility Evaluation System for Polymeric Micro- and Nanoparticles 183

5.4 Construction of Biosensor for Direct Detection in Whole Blood 188

5.5 Conclusion and Prospect 194

References 195

6 The Contribution of Smart Materials and Advanced Clinical Diagnostic Micro-Devices on the Progress and Improvement **of Human Health Care 199
*Teles,* *F.R.R. and Fonseca, L.P.

• 6.1 Introduction 200

  6.2 Physiological Biomarkers as Targets in Clinical Diagnostic Bioassays 202

6.3 Biosensors 205

6.4 Advanced Materials and Nanostructures for Health Care Applications 217 6.5 Applications of Micro-Devices to Some Important Clinical Pathologies 223

6.6 Conclusions and Future Prospects 227

Acknowledgment 227

References 228

7 **Hierarchical Modeling of Elas...