Apoptosis, Cell Signaling, and Human Diseases

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the most innovative and current findings. The contributors are at the forefront of scientific discovery.

Inhalt

Kinases and Phosphatases.- Significance of Protein Kinase A in Cancer.- Protein Kinase C and Apoptosis.- The Role of Phosphoinositide 3-Kinase-Akt Signaling in Virus Infection.- Cyclin-Dependent Kinase 5.- Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance.- MAPK Signaling in Human Diseases.- Serine/Threonine Protein Phosphatases in Apoptosis.- Urokinase/Urokinase Receptor-Mediated Signaling in Cancer.- Molecular Basis of Cell Death.- Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion.- Cyclooxygenase-2 Gene Expression.- Death Receptors.- DNA Damage-Dependent Apoptosis.- The Role of Proteasome in Apoptosis.- Apoptosis Induction in T Lymphocytes by HIV.- Inhibitor of Apoptosis Proteins and Caspases.- Intracellular Pathways Involved in DNA Damage and Repair to Neuronal Apoptosis.- The Biology of Caspases.- Apoptosis and Human Diseases: Molecular Mechanisms.